Inflammation is the most common feature of many chronic diseases and complications, while
playing critical roles in carcinogenesis. Several studies have demonstrated that Nrf2 …

Inflammatory bowel disease (IBD) is a chronic gastrointestinal disease whose incidence has
risen worldwide in recent years. Accumulating evidence shows that oxidative stress plays an …

Increasing oxidative stress, a major characteristic of aging, has been implicated in a variety
of age-related pathologies. In aging, oxidant production from several sources is increased …

Redox signaling regulates physiological self-renewal, proliferation, migration and
differentiation in gastrointestinal epithelium by modulating Wnt/β-catenin and Notch …

Abstract Nrf2 (nuclear factor erythroid 2-related factor 2) is a stress-responsive transcription
factor, associated with cellular homeostasis. Under normal conditions Nrf2 is kept in the …

Abstract The Keap1–Nrf2–ARE pathway is an important antioxidant defense mechanism that
protects cells from oxidative stress and the Keap1–Nrf2 protein–protein interaction (PPI) has …

Inflammatory bowel disease (IBD) is a chronic immune-mediated condition that affects the
digestive system and includes Crohn's disease (CD) and ulcerative colitis (UC). Although …

Ulcerative colitis (UC) is a chronic inflammatory bowel disease involving mainly the
colorectal mucosa and submucosa, the incidence of which has been on the rise in recent …

The transcription factor nuclear factor (erythroid-derived 2)-like 2 (NRF2) is one of the master
regulators that control hundreds of genes containing antioxidant response elements (AREs) …

Nrf2 has gained great attention with respect to its pivotal role in cell and tissue protection.
Primarily defending cells against metabolic, xenobiotic and oxidative stress, Nrf2 is essential …