Subcellular organization of the cAMP signaling pathway

M Zaccolo, A Zerio, MJ Lobo, C Garland - Pharmacological reviews, 2021 - Elsevier
The field of cAMP signaling is witnessing exciting developments with the recognition that
cAMP is compartmentalized and that spatial regulation of cAMP is critical for faithful signal …

Genetically encoded fluorescent biosensors illuminate the spatiotemporal regulation of signaling networks

EC Greenwald, S Mehta, J Zhang - Chemical reviews, 2018 - ACS Publications
Cellular signaling networks are the foundation which determines the fate and function of
cells as they respond to various cues and stimuli. The discovery of fluorescent proteins over …

Intracellular cAMP sensor EPAC: physiology, pathophysiology, and therapeutics development

WG Robichaux III, X Cheng - Physiological reviews, 2018 - journals.physiology.org
This review focuses on one family of the known cAMP receptors, the exchange proteins
directly activated by cAMP (EPACs), also known as the cAMP-regulated guanine nucleotide …

Modelling the molecular mechanisms of synaptic plasticity using systems biology approaches

JH Kotaleski, KT Blackwell - Nature Reviews Neuroscience, 2010 - nature.com
Synaptic plasticity is thought to underlie learning and memory, but the complexity of the
interactions between the ion channels, enzymes and genes that are involved in synaptic …

STEPS: efficient simulation of stochastic reaction–diffusion models in realistic morphologies

I Hepburn, W Chen, S Wils, E De Schutter - BMC systems biology, 2012 - Springer
Background Models of cellular molecular systems are built from components such as
biochemical reactions (including interactions between ligands and membrane-bound …

Phosphodiesterases in heart and vessels-From Physiology to Diseases

Q Fu, Y Wang, C Yan, YK **ang - Physiological Reviews, 2023 - journals.physiology.org
Phosphodiesterases (PDEs) are a superfamily of enzymes that hydrolyze cyclic nucleotides,
including cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate …

Mechanisms restricting diffusion of intracellular cAMP

SR Agarwal, CE Clancy, RD Harvey - Scientific reports, 2016 - nature.com
Although numerous receptors stimulate cAMP production in a wide array of cells, many elicit
distinct, highly localized responses, implying that the subcellular distribution of cAMP is not …

Computational models for calcium-mediated astrocyte functions

T Manninen, R Havela, ML Linne - Frontiers in computational …, 2018 - frontiersin.org
The computational neuroscience field has heavily concentrated on the modeling of neuronal
functions, largely ignoring other brain cells, including one type of glial cell, the astrocytes …

Cyclic AMP compartments and signaling specificity: role of cyclic nucleotide phosphodiesterases

M Conti, D Mika, W Richter - Journal of General Physiology, 2014 - rupress.org
Correspondence to Marco Conti: contim@ obgyn. ucsf. edu Abbreviations used in this
paper: AKAP, A kinase anchoring protein; EPAC, exchange protein directly activated by …

Calcium: amplitude, duration, or location?

RC Evans, KT Blackwell - The Biological Bulletin, 2015 - journals.uchicago.edu
Calcium plays a role in long-term plasticity by triggering postsynaptic signaling pathways for
both the strengthening (LTP) and weakening (LTD) of synapses. Since these are opposing …