Publisher Summary This chapter investigates the anatomy and taxonomy of protein
structures. A protein is a polypeptide chain made up of amino acid residues linked together …

The wealth of information provided by the recent structure determinations of many different
glycosyl hydrolases shows that the substrate specificity and the mode of action of these …

Predictions of the secondary structure of T4 phage lysozyme, made by a number of
investigators on the basis of the amino acid sequence, are compared with the structure of …

A simple diagrammatic representation has been used to show the arrangement of α helices
and β sheets in 31 globular proteins, which are classified into four clearly separated classes …

The present review is focused on the main achievements realized in the lysozyme research
field since the meeting held in 1972 to commemorate the fiftieth anniversary of the discovery …

Phage T4 has provided countless contributions to the paradigms of genetics and
biochemistry. Its complete genome sequence of 168,903 bp encodes about 300 gene …

It is proposed that the stability of a protein can be increased by selected amino acid
substitutions that decrease the configurational entropy of unfolding. Two such substitutions …

Ligand-macromolecule interactions are of fundamental importance in the control of
biological processes. This book applies the principles of linkage thermodynamics to …

Since determination of the myoglobin structure in 1957, X-ray crystallography, as the
anchoring tool of structural biology, has played an instrumental role in deciphering the …

Under physiological conditions, a protein undergoes a spontaneous disorder⇌ order
transition called “folding.” The protein polymer is highly flexible when unfolded but adopts its …