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HPV-associated oropharyngeal cancer: epidemiology, molecular biology and clinical management
Abstract Human papillomavirus (HPV)-positive (HPV+) oropharyngeal squamous cell
carcinoma (OPSCC) has one of the most rapidly increasing incidences of any cancer in high …
carcinoma (OPSCC) has one of the most rapidly increasing incidences of any cancer in high …
Human papillomavirus genomics: Understanding carcinogenicity
Human papillomavirus (HPV) causes virtually all cervical cancers and many cancers at other
anatomical sites in both men and women. However, only 12 of 448 known HPV types are …
anatomical sites in both men and women. However, only 12 of 448 known HPV types are …
Map** clustered mutations in cancer reveals APOBEC3 mutagenesis of ecDNA
Clustered somatic mutations are common in cancer genomes and previous analyses reveal
several types of clustered single-base substitutions, which include doublet-and multi-base …
several types of clustered single-base substitutions, which include doublet-and multi-base …
[HTML][HTML] HPV16 and HPV18 genome structure, expression, and post-transcriptional regulation
Human papillomaviruses (HPV) are a group of small non-enveloped DNA viruses whose
infection causes benign tumors or cancers. HPV16 and HPV18, the two most common high …
infection causes benign tumors or cancers. HPV16 and HPV18, the two most common high …
[HTML][HTML] Persistent human papillomavirus infection
Simple Summary The success of HPV as an infectious agent lies not within its ability to
cause disease, but rather in the adeptness of the virus to establish long-term persistent …
cause disease, but rather in the adeptness of the virus to establish long-term persistent …
APOBEC: A molecular driver in cervical cancer pathogenesis
Cervical cancer is one of the foremost common cancers in women. Human papillomavirus
(HPV) infection remains a major risk factor of cervical cancer. In addition, numerous other …
(HPV) infection remains a major risk factor of cervical cancer. In addition, numerous other …
[HTML][HTML] The drivers, mechanisms, and consequences of genome instability in HPV-driven cancers
Simple Summary Cells infected with high-risk human papillomaviruses (HPV) can
accumulate DNA damage and eventually transform into HPV-driven cancers. Genome …
accumulate DNA damage and eventually transform into HPV-driven cancers. Genome …
[HTML][HTML] Human APOBEC3 variations and viral infection
Human APOBEC3 (apolipoprotein B mRNA-editing catalytic polypeptide-like 3) enzymes
are capable of inhibiting a wide range of endogenous and exogenous viruses using …
are capable of inhibiting a wide range of endogenous and exogenous viruses using …
Leveraging extrachromosomal DNA to fine-tune trials of targeted therapy for glioblastoma: opportunities and challenges
Glioblastoma evolution is facilitated by intratumour heterogeneity, which poses a major
hurdle to effective treatment. Evidence indicates a key role for oncogene amplification on …
hurdle to effective treatment. Evidence indicates a key role for oncogene amplification on …
Recent advances in treating female genital human papillomavirus related neoplasms with topical imiquimod
Human papillomavirus (HPV) encompasses a group of viruses that infect the skin and
mucous membranes. In the presence of certain factors, persistent infection with high‐risk …
mucous membranes. In the presence of certain factors, persistent infection with high‐risk …