A review of healthy and fibrotic myocardium microstructure modeling and corresponding intracardiac electrograms

J Sánchez, A Loewe - Frontiers in Physiology, 2022 - frontiersin.org
Computational simulations of cardiac electrophysiology provide detailed information on the
depolarization phenomena at different spatial and temporal scales. With the development of …

Evaluating computational efforts and physiological resolution of mathematical models of cardiac tissue

KH Jæger, JD Trotter, X Cai, H Arevalo, A Tveito - Scientific Reports, 2024 - nature.com
Computational techniques have significantly advanced our understanding of cardiac
electrophysiology, yet they have predominantly concentrated on averaged models that do …

Modeling excitable cells with the EMI equations: Spectral analysis and iterative solution strategy

P Benedusi, P Ferrari, ME Rognes… - Journal of Scientific …, 2024 - Springer
In this work, we are interested in solving large linear systems stemming from the extra–
membrane–intra model, which is employed for simulating excitable tissues at a cellular …

Intercalated disk nanoscale structure regulates cardiac conduction

N Moise, HL Struckman, C Dagher… - Journal of General …, 2021 - rupress.org
The intercalated disk (ID) is a specialized subcellular region that provides electrical and
mechanical connections between myocytes in the heart. The ID has a clearly defined …

Convergence analysis of BDDC preconditioners for composite DG discretizations of the cardiac cell-by-cell model

NMM Huynh, F Chegini, LF Pavarino, M Weiser… - SIAM Journal on …, 2023 - SIAM
A balancing domain decomposition by constraints (BDDC) preconditioner is constructed and
analyzed for the solution of composite discontinuous Galerkin discretizations of reaction …

Scalable approximation and solvers for ionic electrodiffusion in cellular geometries

P Benedusi, AJ Ellingsrud, H Herlyng… - SIAM Journal on Scientific …, 2024 - SIAM
The activity and dynamics of excitable cells are fundamentally regulated and moderated by
extracellular and intracellular ion concentrations and their electric potentials. The increasing …

From millimeters to micrometers; re-introducing myocytes in models of cardiac electrophysiology

KH Jæger, AG Edwards, WR Giles, A Tveito - Frontiers in Physiology, 2021 - frontiersin.org
Computational modeling has contributed significantly to present understanding of cardiac
electrophysiology including cardiac conduction, excitation-contraction coupling, and the …

Properties of cardiac conduction in a cell-based computational model

KH Jæger, AG Edwards, A McCulloch… - PLoS computational …, 2019 - journals.plos.org
The conduction of electrical signals through cardiac tissue is essential for maintaining the
function of the heart, and conduction abnormalities are known to potentially lead to life …

Localization of Na+ channel clusters in narrowed perinexi of gap junctions enhances cardiac impulse transmission via ephaptic coupling: a model study

E Ivanovic, JP Kucera - The Journal of physiology, 2021 - Wiley Online Library
It has been proposed that when gap junctional coupling is reduced in cardiac tissue, action
potential propagation can be supported via ephaptic coupling, a mechanism mediated by …

[HTML][HTML] Boundary integral formulation of the cell-by-cell model of cardiac electrophysiology

GR de Souza, R Krause, S Pezzuto - Engineering Analysis with Boundary …, 2024 - Elsevier
We propose a boundary element method for the accurate solution of the cell-by-cell
bidomain model of electrophysiology. The cell-by-cell model, also called Extracellular …