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A review of healthy and fibrotic myocardium microstructure modeling and corresponding intracardiac electrograms
Computational simulations of cardiac electrophysiology provide detailed information on the
depolarization phenomena at different spatial and temporal scales. With the development of …
depolarization phenomena at different spatial and temporal scales. With the development of …
Evaluating computational efforts and physiological resolution of mathematical models of cardiac tissue
Computational techniques have significantly advanced our understanding of cardiac
electrophysiology, yet they have predominantly concentrated on averaged models that do …
electrophysiology, yet they have predominantly concentrated on averaged models that do …
Modeling excitable cells with the EMI equations: Spectral analysis and iterative solution strategy
In this work, we are interested in solving large linear systems stemming from the extra–
membrane–intra model, which is employed for simulating excitable tissues at a cellular …
membrane–intra model, which is employed for simulating excitable tissues at a cellular …
Intercalated disk nanoscale structure regulates cardiac conduction
N Moise, HL Struckman, C Dagher… - Journal of General …, 2021 - rupress.org
The intercalated disk (ID) is a specialized subcellular region that provides electrical and
mechanical connections between myocytes in the heart. The ID has a clearly defined …
mechanical connections between myocytes in the heart. The ID has a clearly defined …
Convergence analysis of BDDC preconditioners for composite DG discretizations of the cardiac cell-by-cell model
A balancing domain decomposition by constraints (BDDC) preconditioner is constructed and
analyzed for the solution of composite discontinuous Galerkin discretizations of reaction …
analyzed for the solution of composite discontinuous Galerkin discretizations of reaction …
Scalable approximation and solvers for ionic electrodiffusion in cellular geometries
The activity and dynamics of excitable cells are fundamentally regulated and moderated by
extracellular and intracellular ion concentrations and their electric potentials. The increasing …
extracellular and intracellular ion concentrations and their electric potentials. The increasing …
From millimeters to micrometers; re-introducing myocytes in models of cardiac electrophysiology
Computational modeling has contributed significantly to present understanding of cardiac
electrophysiology including cardiac conduction, excitation-contraction coupling, and the …
electrophysiology including cardiac conduction, excitation-contraction coupling, and the …
Properties of cardiac conduction in a cell-based computational model
The conduction of electrical signals through cardiac tissue is essential for maintaining the
function of the heart, and conduction abnormalities are known to potentially lead to life …
function of the heart, and conduction abnormalities are known to potentially lead to life …
Localization of Na+ channel clusters in narrowed perinexi of gap junctions enhances cardiac impulse transmission via ephaptic coupling: a model study
E Ivanovic, JP Kucera - The Journal of physiology, 2021 - Wiley Online Library
It has been proposed that when gap junctional coupling is reduced in cardiac tissue, action
potential propagation can be supported via ephaptic coupling, a mechanism mediated by …
potential propagation can be supported via ephaptic coupling, a mechanism mediated by …
[HTML][HTML] Boundary integral formulation of the cell-by-cell model of cardiac electrophysiology
We propose a boundary element method for the accurate solution of the cell-by-cell
bidomain model of electrophysiology. The cell-by-cell model, also called Extracellular …
bidomain model of electrophysiology. The cell-by-cell model, also called Extracellular …