Multifunctional scaffolds for bone repair following age-related biological decline: Promising prospects for smart biomaterial-driven technologies
JD Schwartzman, M McCall, Y Ghattas… - Biomaterials, 2024 - Elsevier
The repair of large bone defects due to trauma, disease, and infection can be exceptionally
challenging in the elderly. Despite best clinical practice, bone regeneration within …
challenging in the elderly. Despite best clinical practice, bone regeneration within …
Purinergic signaling in diabetes and metabolism
Purinergic signaling, a concept originally formulated by the late Geoffrey Burnstock (1929–
2020), was found to modulate pathways in every physiological system. In metabolic …
2020), was found to modulate pathways in every physiological system. In metabolic …
Mesenchymal stromal cells from myelodysplastic and acute myeloid leukemia patients display in vitro reduced proliferative potential and similar capacity to support …
Abstract Background Mesenchymal stromal cells (MSCs) are an essential element of the
bone marrow (BM) microenvironment, playing a crucial function in regulating hematopoietic …
bone marrow (BM) microenvironment, playing a crucial function in regulating hematopoietic …
Canonical Wnt signaling differently modulates osteogenic differentiation of mesenchymal stem cells derived from bone marrow and from periodontal ligament under …
Background Cellular plasticity and complex functional requirements of the periodontal
ligament (PDL) assume a local stem cell (SC) niche to maintain tissue homeostasis and …
ligament (PDL) assume a local stem cell (SC) niche to maintain tissue homeostasis and …
Alpl prevents bone ageing sensitivity by specifically regulating senescence and differentiation in mesenchymal stem cells
Mutations in the liver/bone/kidney alkaline phosphatase (Alpl) gene cause
hypophosphatasia (HPP) and early-onset bone dysplasia, suggesting that this gene is a key …
hypophosphatasia (HPP) and early-onset bone dysplasia, suggesting that this gene is a key …
Bone marrow adipose tissue and skeletal health
Abstract Purpose of Review To summarize and discuss recent progress and novel signaling
mechanisms relevant to bone marrow adipocyte formation and its physiological …
mechanisms relevant to bone marrow adipocyte formation and its physiological …
The MSC curtain that stops the immune system
AI Caplan, JM Sorrell - Immunology letters, 2015 - Elsevier
We have evolved cellular mechanisms for protecting us from disabling intruders or injuries.
The Mesenchymal Stem Cell, MSC, is derived from perivascular cells, pericytes that are …
The Mesenchymal Stem Cell, MSC, is derived from perivascular cells, pericytes that are …
Spatial control of adult stem cell fate using nanotopographic cues
Adult stem cells hold great promise as a source of diverse terminally differentiated cell types
for tissue engineering applications. However, due to the complexity of chemical and …
for tissue engineering applications. However, due to the complexity of chemical and …
Purinergic receptors in adipose tissue as potential targets in metabolic disorders
M Tozzi, I Novak - Frontiers in pharmacology, 2017 - frontiersin.org
Extracellular nucleosides and nucleotides, such as adenosine and adenosine triphosphate
(ATP), are involved in many physiological and pathological processes in adipose tissue …
(ATP), are involved in many physiological and pathological processes in adipose tissue …
Physiological cyclic hydrostatic pressure induces osteogenic lineage commitment of human bone marrow stem cells: a systematic study
E Stavenschi, MA Corrigan, GP Johnson… - Stem Cell Research & …, 2018 - Springer
Background Physical loading is necessary to maintain bone tissue integrity. Loading-
induced fluid shear is recognised as one of the most potent bone micromechanical cues and …
induced fluid shear is recognised as one of the most potent bone micromechanical cues and …