Molecular and evolutionary processes generating variation in gene expression

MS Hill, P Vande Zande, PJ Wittkopp - Nature Reviews Genetics, 2021 - nature.com
Heritable variation in gene expression is common within and between species. This
variation arises from mutations that alter the form or function of molecular gene regulatory …

Sequencing pools of individuals—mining genome-wide polymorphism data without big funding

C Schlötterer, R Tobler, R Kofler, V Nolte - Nature Reviews Genetics, 2014 - nature.com
The analysis of polymorphism data is becoming increasingly important as a complementary
tool to classical genetic analyses. Nevertheless, despite plunging sequencing costs …

Tempo and mode of regulatory evolution in Drosophila

JD Coolon, CJ McManus, KR Stevenson… - Genome …, 2014 - genome.cshlp.org
Genetic changes affecting gene expression contribute to phenotypic divergence; thus,
understanding how regulatory networks controlling gene expression change over time is …

[PDF][PDF] Evolutionary dynamics of regulatory changes underlying gene expression divergence among Saccharomyces species

BPH Metzger, PJ Wittkopp… - Genome biology and …, 2017 - academic.oup.com
Heritable changes in gene expression are important contributors to phenotypic differences
within and between species and are caused by mutations in cis-regulatory elements and …

Temperature Stress Mediates Decanalization and Dominance of Gene Expression in Drosophila melanogaster

J Chen, V Nolte, C Schlötterer - PLoS genetics, 2015 - journals.plos.org
The regulatory architecture of gene expression remains an area of active research. Here, we
studied how the interplay of genetic and environmental variation affects gene expression by …

Cis- and Trans-regulatory Effects on Gene Expression in a Natural Population of Drosophila melanogaster

N Osada, R Miyagi, A Takahashi - Genetics, 2017 - academic.oup.com
Cis-and trans-regulatory mutations are important contributors to transcriptome evolution.
Quantifying their relative contributions to intraspecific variation in gene expression is …

Few Fixed Variants between Trophic Specialist Pupfish Species Reveal Candidate Cis-Regulatory Alleles Underlying Rapid Craniofacial Divergence

JA McGirr, CH Martin - Molecular biology and evolution, 2021 - academic.oup.com
Investigating closely related species that rapidly evolved divergent feeding morphology is a
powerful approach to identify genetic variation underlying variation in complex traits. This …

Evolution of gene regulation during transcription and translation

Z Wang, X Sun, Y Zhao, X Guo, H Jiang… - Genome biology and …, 2015 - academic.oup.com
Understanding how gene regulation evolves is a key area in the current evolutionary field.
Gene regulation occurs at various levels. Previous work on the evolution of gene regulation …

The Interplay of Temperature and Genotype on Patterns of Alternative Splicing in Drosophila melanogaster

AM Jakšić, C Schlötterer - Genetics, 2016 - academic.oup.com
Alternative splicing is the highly regulated process of variation in the removal of introns from
premessenger-RNA transcripts. The consequences of alternative splicing on the phenotype …

Gene regulatory evolution during speciation in a songbird

JH Davidson, CN Balakrishnan - G3: Genes, Genomes …, 2016 - academic.oup.com
Over the last decade, tremendous progress has been made toward a comparative
understanding of gene regulatory evolution. However, we know little about how gene …