The regulation of telomere length in mammals is crucial for chromosome end-cap** and
thus for maintaining genome stability and cellular lifespan. This process requires …

Osteoarthritis is the most common joint disorder with increasing prevalence due to aging of
the population. Its multi-factorial etiology includes oxidative stress and the overproduction of …

Telomeres are protein–DNA complexes that protect chromosome ends from illicit ligation
and resection. Telomerase is a ribonucleoprotein enzyme that synthesizes telomeric DNA to …

Telomeres, the ends of eukaryotic chromosomes, play pivotal parts in ageing and cancer
and are targets of DNA damage and the DNA damage response,,,–. Little is known about the …

Proteins that bind both DNA and RNA typify the ability of a single gene product to perform
multiple functions. Such DNA-and RNA-binding proteins (DRBPs) have unique functional …

Added by telomerase, arrays of TTAGGG repeats specify the ends of human chromosomes.
A complex formed by six telomere-specific proteins associates with this sequence and …

The genomes of prokaryotes and eukaryotic organelles are usually circular as are most
plasmids and viral genomes. In contrast, the nuclear genomes of eukaryotes are organized …

Telomeres, the ends of linear eukaryotic chromosomes, are characterized by the presence
of multiple repeats of a short DNA sequence. This telomeric DNA is protected from illicit …

Mammalian telomeres are formed by tandem repeats of the TTAGGG sequence, which are
progressively lost with each round of cell division. Telomere protection requires a minimal …

DNA G-quadruplexes are DNA secondary structures formed in specific G-rich sequences.
DNA sequences that can form G-quadruplexes have been found in regions with biological …