The firmicutes/bacteroidetes ratio: a relevant marker of gut dysbiosis in obese patients?
The gut microbiota is emerging as a promising target for the management or prevention of
inflammatory and metabolic disorders in humans. Many of the current research efforts are …
inflammatory and metabolic disorders in humans. Many of the current research efforts are …
Disease suppressive soils: new insights from the soil microbiome
Soils suppressive to soilborne pathogens have been identified worldwide for almost 60
years and attributed mainly to suppressive or antagonistic microorganisms. Rather than …
years and attributed mainly to suppressive or antagonistic microorganisms. Rather than …
Normalization and microbial differential abundance strategies depend upon data characteristics
Background Data from 16S ribosomal RNA (rRNA) amplicon sequencing present
challenges to ecological and statistical interpretation. In particular, library sizes often vary …
challenges to ecological and statistical interpretation. In particular, library sizes often vary …
[HTML][HTML] Metagenomic shotgun sequencing and unbiased metabolomic profiling identify specific human gut microbiota and metabolites associated with immune …
This is the first prospective study of the effects of human gut microbiota and metabolites on
immune checkpoint inhibitor (ICT) response in metastatic melanoma patients. Whereas …
immune checkpoint inhibitor (ICT) response in metastatic melanoma patients. Whereas …
Establishing causality: opportunities of synthetic communities for plant microbiome research
Plant microbiome research highlights the importance of indigenous microbial communities
for host phenotypes such as growth and health. It aims to discover the molecular basis by …
for host phenotypes such as growth and health. It aims to discover the molecular basis by …
Systematic improvement of amplicon marker gene methods for increased accuracy in microbiome studies
Amplicon-based marker gene surveys form the basis of most microbiome and other
microbial community studies. Such PCR-based methods have multiple steps, each of which …
microbial community studies. Such PCR-based methods have multiple steps, each of which …
Assessment of variation in microbial community amplicon sequencing by the Microbiome Quality Control (MBQC) project consortium
In order for human microbiome studies to translate into actionable outcomes for health, meta-
analysis of reproducible data from population-scale cohorts is needed. Achieving sufficient …
analysis of reproducible data from population-scale cohorts is needed. Achieving sufficient …
Transplantation of fecal microbiota from patients with irritable bowel syndrome alters gut function and behavior in recipient mice
Irritable bowel syndrome (IBS) is a common disorder characterized by altered gut function
and often is accompanied by comorbid anxiety. Although changes in the gut microbiota have …
and often is accompanied by comorbid anxiety. Although changes in the gut microbiota have …
Optimizing methods and dodging pitfalls in microbiome research
Research on the human microbiome has yielded numerous insights into health and disease,
but also has resulted in a wealth of experimental artifacts. Here, we present suggestions for …
but also has resulted in a wealth of experimental artifacts. Here, we present suggestions for …
Fetal meconium does not have a detectable microbiota before birth
KM Kennedy, MJ Gerlach, T Adam, MM Heimesaat… - Nature …, 2021 - nature.com
Microbial colonization of the human intestine impacts host metabolism and immunity;
however, exactly when colonization occurs is unclear. Although many studies have reported …
however, exactly when colonization occurs is unclear. Although many studies have reported …