The recycling of membrane proteins from endosomes to the cell surface is vital for cell
signaling and survival. Retriever, a trimeric complex of vacuolar protein-sorting-associated …

Rheumatoid arthritis (RA) is an autoimmune inflammatory disease that affects multiple
organs and systems in the human body, often leading to disability. Its pathogenesis is …

Celastrol, a compound derived from traditional Chinese medicine, has therapeutic effects
and has been used to treat inflammation-related diseases, cancer, cardiovascular diseases …

Tripterygium wilfordii (TW) preparations have been utilized in China for treating rheumatoid
arthritis and autoimmune diseases. However, their clinical use is limited due to reproductive …

Previous study has indicated that Celastrol (Cel) has various physiological and
pharmacological effects, including antibacterial, antioxidant, pro-apoptotic, anticancer and …

Hedyotis diffusa Willd (HDW) possesses heat-clearing, detoxification, anti-cancer, and anti-
inflammatory properties. However, its effects on rheumatoid arthritis (RA) remain under …

Obese asthma is a unique asthma phenotype that decreases sensitivity to inhaled
corticosteroids, and currently lacks efficient therapeutic medication. Celastrol, a powerful …

Lung cancer has one of the highest mortality rates worldwide, with non-small-cell lung
cancer (NSCLC) constituting approximately 85% of all cases. Demethylzeylasteral (DEM) …

Phylloporia pulla, a macrofungal species in the Hymenochaetales, Basidiomycota, is known
to enhance the nutritional and bioactive properties of rice through co-fermentation; however …

Background A balanced protein homeostasis network helps cholangiocarcinoma (CCA)
maintain their oncogenic growth, and disrupting proteostasis therapeutically will induce …