Tau is a microtubule-associated protein that has a role in stabilizing neuronal microtubules
and thus in promoting axonal outgrowth. Structurally, tau is a natively unfolded protein, is …

▪ Abstract The defining neuropathological characteristics of Alzheimer's disease are
abundant filamentous tau lesions and deposits of fibrillar amyloid β peptides. Prominent …

Microtubules (MTs) play a fundamental role in many vital processes such as cell division
and neuronal activity. They are key structural and functional elements in axons, supporting …

Advances in our understanding of the mechanisms of tau-mediated neurodegeneration in
Alzheimer's disease (AD) and related tauopathies, which are characterized by prominent …

Alzheimer's disease (AD) is the leading cause of dementia in elderly people. Amyloid beta
(Aβ) deposits and neurofibrillary tangles are the major pathological features in an …

Tau proteins belong to the family of microtubule-associated proteins. They are mainly
expressed in neurons where they play an important role in the assembly of tubulin …

In 1975, tau protein was isolated as a microtubule-associated factor from the porcine brain.
In the previous year, a paired helical filament (PHF) protein had been identified in …

Filamentous tau inclusions are hallmarks of Alzheimer's disease (AD) and related
tauopathies, but earlier pathologies may herald disease onset. To investigate this, we …

Abstract α-Synuclein (α-Syn) is a 14 kDa protein of unknown function that has been
implicated in the pathophysiology of Parkinson's disease (PD). Here, we show that α-Syn …

Most neurodegenerative diseases are characterized by intracellular aggregates of insoluble
proteins. As for the majority of these disorders, aetiology and pathogenesis are only poorly …