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Understanding the genetic basis of variation in meiotic recombination: past, present, and future
SE Johnston - Molecular Biology and Evolution, 2024 - academic.oup.com
Meiotic recombination is a fundamental feature of sexually reproducing species. It is often
required for proper chromosome segregation and plays important role in adaptation and the …
required for proper chromosome segregation and plays important role in adaptation and the …
PRDM9 and its role in genetic recombination
K Paigen, PM Petkov - Trends in Genetics, 2018 - cell.com
PRDM9 is a zinc finger protein that binds DNA at specific locations in the genome where it
trimethylates histone H3 at lysines 4 and 36 at surrounding nucleosomes. During meiosis in …
trimethylates histone H3 at lysines 4 and 36 at surrounding nucleosomes. During meiosis in …
Natural selection interacts with recombination to shape the evolution of hybrid genomes
To investigate the consequences of hybridization between species, we studied three
replicate hybrid populations that formed naturally between two swordtail fish species …
replicate hybrid populations that formed naturally between two swordtail fish species …
Stable recombination hotspots in birds
The DNA-binding protein PRDM9 has a critical role in specifying meiotic recombination
hotspots in mice and apes, but it appears to be absent from other vertebrate species …
hotspots in mice and apes, but it appears to be absent from other vertebrate species …
Variation in the molecular clock of primates
Events in primate evolution are often dated by assuming a constant rate of substitution per
unit time, but the validity of this assumption remains unclear. Among mammals, it is well …
unit time, but the validity of this assumption remains unclear. Among mammals, it is well …
Patterns of recombination in snakes reveal a tug-of-war between PRDM9 and promoter-like features
In some mammals, notably humans, recombination occurs almost exclusively where the
protein PRDM9 binds, whereas in vertebrates lacking an intact PRDM9, such as birds and …
protein PRDM9 binds, whereas in vertebrates lacking an intact PRDM9, such as birds and …
Selection against admixture and gene regulatory divergence in a long-term primate field study
Genetic admixture is central to primate evolution. We combined 50 years of field
observations of immigration and group demography with genomic data from~ 9 generations …
observations of immigration and group demography with genomic data from~ 9 generations …
Recombination-aware phylogenomics reveals the structured genomic landscape of hybridizing cat species
Current phylogenomic approaches implicitly assume that the predominant phylogenetic
signal within a genome reflects the true evolutionary history of organisms, without assessing …
signal within a genome reflects the true evolutionary history of organisms, without assessing …
Evolutionary mysteries in meiosis
Meiosis is a key event of sexual life cycles in eukaryotes. Its mechanistic details have been
uncovered in several model organisms, and most of its essential features have received …
uncovered in several model organisms, and most of its essential features have received …
Repeated losses of PRDM9-directed recombination despite the conservation of PRDM9 across vertebrates
Studies of highly diverged species have revealed two mechanisms by which meiotic
recombination is directed to the genome—through PRDM9 binding or by targeting promoter …
recombination is directed to the genome—through PRDM9 binding or by targeting promoter …