Synthetic nanoassemblies for regulating organelles: from molecular design to precision therapeutics

Y Guo, P Li, X Guo, C Yao, D Yang - ACS nano, 2024 - ACS Publications
Each organelle referring to a complex multiorder architecture executes respective biological
processes via its distinct spatial organization and internal microenvironment. As the …

Advancements in phasor-based FLIM: multi-component analysis and lifetime probes in biological imaging

D Li, X Liu, F Dong, W Li - Journal of Materials Chemistry B, 2025 - pubs.rsc.org
Fluorescence lifetime imaging microscopy (FLIM) is a reliable method that achieves imaging
by detecting fluorescence lifetimes within samples. Owing to its unique temporal …

Precise Regulations at the Subcellular Level through Intracellular Polymerization, Assembly, and Transformation

L He, F Meng, R Chen, J Qin, M Sun, Z Fan, J Du - JACS Au, 2024 - ACS Publications
A living cell is an intricate machine that creates subregions to operate cell functions
effectively. Subcellular dysfunction has been identified as a potential druggable target for …

Multi‐Step Assembly of an RNA‐Liposome Nanoparticle Formulation Revealed by Real‐Time, Single‐Particle Quantitative Imaging

MC Chung, HR Mendez‐Gomez, D Soni… - Advanced …, 2025 - Wiley Online Library
Self‐assembly plays a critical role in nanoparticle‐based applications. However, it remains
challenging to monitor the self‐assembly of multi‐component nanomaterials at a single …

Time‐resolved Photoluminescence Determined the Dynamic Self‐Assembly for the Interactions Between Nanofibers and Proteins

R Zhang, H Xu, C Ren, Q Yao, Y Gao - Small, 2025 - Wiley Online Library
The interactions between supramolecular nanofibers and proteins are crucial for functional
biomaterials while there is lack of direct method to interpret supramolecular nanofiber …

Synthetic intracellular nanostructures enhance cytotoxic T cell function via assembly-driven chemical engineering

S Chagri, A Burgstaller, C Schirra, J Link, Z Zhou… - 2024 - chemrxiv.org
Nature achieves diverse biological functions through structure formation. Inspired by the
controlled formation of polypeptide nanostructures in cells, synthetic methods have been …

Visible Light-Controlled Intracellular Synthesis of Supramolecular Peptide Nanostructures

Y Ren, Z Zhou, I Harley, Ö Aydin, J **ng, K Maxeiner… - 2024 - chemrxiv.org
The complex dynamics and transience of supramolecular pathways in living cellular
environments impede the correlation between diverse hierarchical species and their …

Intracellular Formation of Synthetic Peptide Nanostructures Causes Mitochondrial Disruption and Cell Death in Tumor Spheroids

S Chagri, K Maxeiner, L Förch, J Link, P Roth, R Meyer… - 2024 - chemrxiv.org
Supramolecular assemblies found in nature demonstrate the concept of creating
functionality through structure formation. In recent years, these complex natural architectures …