Recent advances in understanding the role of mitochondrial dysfunction in
neurodegenerative diseases have expanded the opportunities for neurotherapeutics …

It has long been recognized that an increase of reactive oxygen species (ROS) can modify
the cell‐signaling proteins and have functional consequences, which successively mediate …

Protein aggregation causes α-synuclein to switch from its physiological role to a pathological
toxic gain of function. Under physiological conditions, monomeric α-synuclein improves ATP …

The endoplasmic reticulum (ER) and mitochondria cannot be considered as static structures,
as they intimately communicate, forming very dynamic platforms termed mitochondria …

Melatonin, more commonly known as the sleep hormone, is mainly secreted by the pineal
gland in dark conditions and regulates the circadian rhythm of the organism. Its intrinsic …

Acute myocardial infarction (AMI) is a leading cause of morbidity and mortality. Reperfusion
strategies are the current standard therapy for AMI. However, they may result in paradoxical …

Aging has been linked to several degenerative processes that, through the accumulation of
molecular and cellular damage, can progressively lead to cell dysfunction and organ failure …

Oxidative and reductive stress are dual dynamic phases experienced by the cells
undergoing adaptation towards endogenous or exogenous noxious stimulus. The former …

In this review, we summarize current knowledge of perhaps one of the most intriguing
phenomena in cell biology: the mitochondrial permeability transition pore (mPTP). This …

Calcium (Ca 2+) is considered one of the most-important biological cations, because it is
implicated in cell physiopathology and cell fate through a finely tuned signaling system. In …