Till date, only three techniques namely Zinc Finger Nuclease (ZFN), Transcription-Activator
Like Effector Nucleases (TALEN) and Clustered Regularly Interspaced Short Palindromic …

A marked decrease in malaria-related deaths worldwide has been attributed to the
administration of effective antimalarials against Plasmodium falciparum, in particular …

Genome manipulation in the malaria parasite Plasmodium falciparum remains largely
intractable and improved genomic tools are needed to further understand pathogenesis and …

Current systems to study essential genes in the human malaria parasite Plasmodium
falciparum are often inefficient and time intensive, and they depend on the genetic …

The life cycles of many parasites involve transitions between disparate host species,
requiring these parasites to go through multiple developmental stages adapted to each of …

The emergence of artemisinin resistance in Southeast Asia imperils efforts to reduce the
global malaria burden. We genetically modified the Plasmodium falciparum K13 locus using …

Current technology enables the production of highly specific genome modifications with
excellent efficiency and specificity. Key to this capability are targetable DNA cleavage …

The widely used antimalarial combination therapy dihydroartemisinin+ piperaquine (DHA+
PPQ) has failed in Cambodia. Here, we perform a genomic analysis that reveals a rapid …

The emergence and spread of drug-resistant Plasmodium falciparum impedes global efforts
to control and eliminate malaria. For decades, treatment of malaria has relied on …

Achieving a malaria-free world presents exciting scientific challenges as well as
overwhelming health, equity, and economic benefits. WHO and countries are setting …