The MHC locus and genetic susceptibility to autoimmune and infectious diseases
In the past 50 years, variants in the major histocompatibility complex (MHC) locus, also
known as the human leukocyte antigen (HLA), have been reported as major risk factors for …
known as the human leukocyte antigen (HLA), have been reported as major risk factors for …
The dual role of HLA-C in tolerance and immunity at the maternal-fetal interface
H Papúchová, TB Meissner, Q Li… - Frontiers in …, 2019 - frontiersin.org
To establish a healthy pregnancy, maternal immune cells must tolerate fetal allo-antigens
and remain competent to respond to infections both systemically and in placental tissues …
and remain competent to respond to infections both systemically and in placental tissues …
Genome-wide analysis provides genetic evidence that ACE2 influences COVID-19 risk and yields risk scores associated with severe disease
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enters human host cells
via angiotensin-converting enzyme 2 (ACE2) and causes coronavirus disease 2019 (COVID …
via angiotensin-converting enzyme 2 (ACE2) and causes coronavirus disease 2019 (COVID …
An evolutionarily conserved function of polycomb silences the MHC class I antigen presentation pathway and enables immune evasion in cancer
ML Burr, CE Sparbier, KL Chan, YC Chan… - Cancer cell, 2019 - cell.com
Loss of MHC class I (MHC-I) antigen presentation in cancer cells can elicit immunotherapy
resistance. A genome-wide CRISPR/Cas9 screen identified an evolutionarily conserved …
resistance. A genome-wide CRISPR/Cas9 screen identified an evolutionarily conserved …
High-density map** of the MHC identifies a shared role for HLA-DRB1* 01: 03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis
P Goyette, G Boucher, D Mallon, E Ellinghaus… - Nature …, 2015 - nature.com
Genome-wide association studies of the related chronic inflammatory bowel diseases (IBD)
known as Crohn's disease and ulcerative colitis have shown strong evidence of association …
known as Crohn's disease and ulcerative colitis have shown strong evidence of association …
Elevated HLA-A expression impairs HIV control through inhibition of NKG2A-expressing cells
The highly polymorphic human leukocyte antigen (HLA) locus encodes cell surface proteins
that are critical for immunity. HLA-A expression levels vary in an allele-dependent manner …
that are critical for immunity. HLA-A expression levels vary in an allele-dependent manner …
HLA imputation and its application to genetic and molecular fine-map** of the MHC region in autoimmune diseases
Variations of human leukocyte antigen (HLA) genes in the major histocompatibility complex
region (MHC) significantly affect the risk of various diseases, especially autoimmune …
region (MHC) significantly affect the risk of various diseases, especially autoimmune …
Relative expression levels of the HLA class-I proteins in normal and HIV-infected cells
The expression level of HLA class-I proteins is known to influence pathological outcomes:
pathogens downregulate HLA to evade host immune responses, host inflammatory …
pathogens downregulate HLA to evade host immune responses, host inflammatory …
Immune modulatory microRNAs involved in tumor attack and tumor immune escape
SB Eichmüller, W Osen, O Mandelboim… - JNCI: Journal of the …, 2017 - academic.oup.com
Current therapies against cancer utilize the patient's immune system for tumor eradication.
However, tumor cells can evade immune surveillance of CD8+ T and/or natural killer (NK) …
However, tumor cells can evade immune surveillance of CD8+ T and/or natural killer (NK) …
The impact of host genetic variation on infection with HIV-1
PJ McLaren, M Carrington - Nature immunology, 2015 - nature.com
The outcome after infection with the human immunodeficiency virus type 1 (HIV-1) is a
complex phenotype determined by interactions among the pathogen, the human host and …
complex phenotype determined by interactions among the pathogen, the human host and …