T helper (Th) cell profiles in pregnancy and recurrent pregnancy losses: Th1/Th2/Th9/Th17/Th22/Tfh cells

W Wang, N Sung, A Gilman-Sachs… - Frontiers in …, 2020 - frontiersin.org
During pregnancy, various immune effectors and molecules participating in the immune-
microenvironment establish specific maternal tolerance toward the semi-allogeneic fetus …

[HTML][HTML] Preeclampsia: linking placental ischemia with maternal endothelial and vascular dysfunction

BA Bakrania, FT Spradley, HA Drummond… - Comprehensive …, 2020 - ncbi.nlm.nih.gov
Preeclampsia (PE), a hypertensive disorder, occurs in 3% to 8% of pregnancies in the
United States and affects over 200,000 women and newborns per year. The United States …

Animal models of preeclampsia: causes, consequences, and interventions

KL Gatford, PH Andraweera, CT Roberts, AS Care - Hypertension, 2020 - Am Heart Assoc
Preeclampsia is a common pregnancy complication, affecting 2% to 8% of pregnancies
worldwide, and is an important cause of both maternal and fetal morbidity and mortality …

Role of hormones in the pregnancy and sex‐specific outcomes to infections with respiratory viruses

O Cervantes, I Cruz Talavera, E Every… - Immunological …, 2022 - Wiley Online Library
Pregnant women infected with pathogenic respiratory viruses, such as influenza A viruses
(IAV) and coronaviruses, are at higher risk for mortality, hospitalization, preterm birth, and …

Differentiation of T cells producing interleukin‐17 (Th17) against the background of exogenous melatonin during pregnancy

NS Glebezdina, IV Nekrasova, AA Olina… - Journal of Pineal …, 2023 - Wiley Online Library
The population of T lymphocytes producing IL‐17 (Th17) plays a dual role during pregnancy
and its activity is tightly controlled during this period. One of the factors involved in this …

Adoptive transfer of placental ischemia‐stimulated natural killer cells causes a preeclampsia‐like phenotype in pregnant rats

OK Travis, C Baik, GA Tardo, L Amaral… - American Journal of …, 2021 - Wiley Online Library
Abstract Problem The Reduced Uterine Perfusion Pressure (RUPP) rat model of placental
ischemia recapitulates many characteristics of preeclampsia including maternal …

Identification of MARK2, CCDC71, GATA2, and KLRC3 as candidate diagnostic genes and potential therapeutic targets for repeated implantation failure with …

M Zhang, T Ge, Y Zhang, X La - Frontiers in Immunology, 2023 - frontiersin.org
Background Antiphospholipid syndrome (APS) is a group of clinical syndromes of
thrombosis or adverse pregnancy outcomes caused by antiphospholipid antibodies, which …

Mechanisms of inflammation modulation by different immune cells in hypertensive nephropathy

X Hao, Y Liu, D Hailaiti, Y Gong, X Zhang… - Frontiers in …, 2024 - frontiersin.org
Hypertensive nephropathy (HTN) is the second leading cause of end-stage renal disease
(ESRD) and a chronic inflammatory disease. Persistent hypertension leads to lesions of …

Interleukin-17 signaling mediates cytolytic natural killer cell activation in response to placental ischemia

OK Travis, D White, C Baik… - American Journal …, 2020 - journals.physiology.org
T-helper (TH) 17s, IL-17, and cytolytic natural killer cells (cNKs) are increased in
preeclampsia and contribute to the hypertension, inflammation, and fetal growth restriction …

Setting a stage: Inflammation during preeclampsia and postpartum

O Herrock, E Deer, B LaMarca - Frontiers in Physiology, 2023 - frontiersin.org
Preeclampsia (PE) is a leading cause of maternal and fetal mortality worldwide. The immune
system plays a critical role in normal pregnancy progression; however, inappropriate …