Oncogenic activation of the phosphatidylinositol-3-kinase (PI3K), protein kinase B
(PKB/AKT), and mammalian target of rapamycin (mTOR) pathway is a frequent event in …

The AGC family of serine/threonine kinases (PKA, PKG, PKC) includes more than 60
members that are critical regulators of numerous cellular functions, including cell cycle and …

Sphingolipids have garnered attention for their role in insulin resistance and lipotoxic cell
death. We have developed transgenic mice inducibly expressing acid ceramidase that …

Ribosomal protein S6 (RPS6) is a component of the 40S small ribosomal subunit and
participates in the control of mRNA translation. Additionally, phospho (p)-RPS6 has been …

▪ Abstract Nerve growth factor (NGF) was discovered 50 years ago as a molecule that
promoted the survival and differentiation of sensory and sympathetic neurons. Its roles in …

Phosphoinositide 3-kinases (PI3Ks) generate specific inositol lipids that have been
implicated in the regulation of cell growth, proliferation, survival, differentiation and …

Elongation factor 2 kinase (eEF2k) phosphorylates and inactivates eEF2. Insulin induces
dephosphorylation of eEF2 and inactivation of eEF2 kinase, and these effects are blocked …

Serum-and glucocorticoid-inducible kinases (SGKs) form a novel family of serine/threonine
kinases that are activated in response to a variety of extracellular stimuli. SGKs are related to …

OBJECTIVE Tumor necrosis factor-α (TNF-α) and interleukin-1 beta (IL-1β) are elevated in
the vitreous of diabetic patients and in retinas of diabetic rats associated with increased …

The discovery in the early 1980s that protein kinase C is 'the receptor'for the tumor-
promoting phorbol esters catapulted this enzyme to the forefront of research in signal …