Sumoylation is an essential post-translational modification that is catalysed by a small
number of modifying enzymes but regulates thousands of target proteins in a dynamic …

SUMOylation is an important and highly dynamic post-translational modification (PTM)
process of protein, and its disequilibrium may cause various diseases, such as cancers and …

Replication protein A (RPA) is a ubiquitous ssDNA-binding protein that functions in many
DNA processing pathways to maintain genome integrity. Recent studies suggest that RPA …

The single-stranded DNA (ssDNA) binding protein complex RPA plays a critical role in
promoting DNA replication and multiple DNA repair pathways. However, how RPA is …

Errors in chromosome segregation underlie genomic instability associated with cancers.
Resolution of replication and recombination intermediates and protection of vulnerable …

Human single-stranded DNA-binding protein homologs hSSB1 (SOSSB1) and hSSB2
(SOSSB2) make a vital impact on maintaining genome stability as the B subunits of the …

Targeting CDC20 can enhance the radiosensitivity of tumor cells, but the function and
mechanism of CDC20 on DNA damage repair response remains vague. To examine that …

Cellular pathways that detect DNA damage are useful for identifying genes that suppress
DNA damage, which can cause genome instability and cancer predisposition syndromes …

Abstract Replication Protein A (RPA) is an essential eukaryotic single-stranded DNA binding
protein that performs a multitude of functions associated with DNA metabolism. i) It binds to …

Broken DNA is a hazard to every living organism. In higher eukaryotes like humans broken
DNA can lead to a variety of diseases, but especially genetic diseases and cancer. To …