Amyloid oligomers: A joint experimental/computational perspective on Alzheimer's disease, Parkinson's disease, type II diabetes, and amyotrophic lateral sclerosis
Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …
Peptide-based supramolecular systems chemistry
Peptide-based supramolecular systems chemistry seeks to mimic the ability of life forms to
use conserved sets of building blocks and chemical reactions to achieve a bewildering array …
use conserved sets of building blocks and chemical reactions to achieve a bewildering array …
Mechanisms and pathology of protein misfolding and aggregation
Despite advances in machine learning-based protein structure prediction, we are still far
from fully understanding how proteins fold into their native conformation. The conventional …
from fully understanding how proteins fold into their native conformation. The conventional …
The expanding amyloid family: Structure, stability, function, and pathogenesis
The hidden world of amyloid biology has suddenly snapped into atomic-level focus,
revealing over 80 amyloid protein fibrils, both pathogenic and functional. Unlike globular …
revealing over 80 amyloid protein fibrils, both pathogenic and functional. Unlike globular …
Self‐assembling peptide‐based hydrogels for wound tissue repair
T Guan, J Li, C Chen, Y Liu - Advanced Science, 2022 - Wiley Online Library
Wound healing is a long‐term, multistage biological process that includes hemostasis,
inflammation, proliferation, and tissue remodeling and requires intelligent designs to provide …
inflammation, proliferation, and tissue remodeling and requires intelligent designs to provide …
Designing artificial metalloenzymes by tuning of the environment beyond the primary coordination sphere
Metalloenzymes catalyze a variety of reactions using a limited number of natural amino
acids and metallocofactors. Therefore, the environment beyond the primary coordination …
acids and metallocofactors. Therefore, the environment beyond the primary coordination …
Machine learning overcomes human bias in the discovery of self-assembling peptides
Peptide materials have a wide array of functions, from tissue engineering and surface
coatings to catalysis and sensing. Tuning the sequence of amino acids that comprise the …
coatings to catalysis and sensing. Tuning the sequence of amino acids that comprise the …
A supramolecular metalloenzyme possessing robust oxidase-mimetic catalytic function
S Xu, H Wu, S Liu, P Du, H Wang, H Yang, W Xu… - Nature …, 2023 - nature.com
Enzymes fold into unique three-dimensional structures to distribute their reactive amino acid
residues, but environmental changes can disrupt their essential folding and lead to …
residues, but environmental changes can disrupt their essential folding and lead to …
Prebiotic peptides: Molecular hubs in the origin of life
The fundamental roles that peptides and proteins play in today's biology makes it almost
indisputable that peptides were key players in the origin of life. Insofar as it is appropriate to …
indisputable that peptides were key players in the origin of life. Insofar as it is appropriate to …
Supramolecular polymers in aqueous media
This review discusses one-dimensional supramolecular polymers that form in aqueous
media. First, naturally occurring supramolecular polymers are described, in particular …
media. First, naturally occurring supramolecular polymers are described, in particular …