How introns enhance gene expression

O Shaul - The international journal of biochemistry & cell biology, 2017 - Elsevier
In many eukaryotes, including mammals, plants, yeast, and insects, introns can increase
gene expression without functioning as a binding site for transcription factors. This …

Introns: the functional benefits of introns in genomes

BS Jo, SS Choi - Genomics & informatics, 2015 - pmc.ncbi.nlm.nih.gov
The intron has been a big biological mystery since it was first discovered in several aspects.
First, all of the completely sequenced eukaryotes harbor introns in the genomic structure …

Dynamic genome evolution in a model fern

DB Marchant, G Chen, S Cai, F Chen, P Schafran… - Nature Plants, 2022 - nature.com
The large size and complexity of most fern genomes have hampered efforts to elucidate
fundamental aspects of fern biology and land plant evolution through genome-enabled …

An Agrobacterium‐delivered CRISPR/Cas9 system for high‐frequency targeted mutagenesis in maize

SN Char, AK Neelakandan… - Plant biotechnology …, 2017 - Wiley Online Library
CRISPR/Cas9 is a powerful genome editing tool in many organisms, including a number of
monocots and dicots. Although the design and application of CRISPR/Cas9 is simpler …

Introns as gene regulators: a brick on the accelerator

AB Rose - Frontiers in genetics, 2019 - frontiersin.org
A picture is beginning to emerge from a variety of organisms that for a subset of genes, the
most important sequences that regulate expression are situated not in the promoter but …

Engineering the push and pull of lipid biosynthesis in oleaginous yeast Yarrowia lipolytica for biofuel production

M Tai, G Stephanopoulos - Metabolic engineering, 2013 - Elsevier
Microbial oil production by heterotrophic organisms is a promising path for the cost-effective
production of biofuels from renewable resources provided high conversion yields can be …

High-efficiency genome editing in plants mediated by a Cas9 gene containing multiple introns

R Grützner, P Martin, C Horn, S Mortensen, EJ Cram… - Plant …, 2021 - cell.com
The recent discovery of the mode of action of the CRISPR/Cas9 system has provided
biologists with a useful tool for generating site-specific mutations in genes of interest. In …

The exon junction complex as a node of post-transcriptional networks

HL Hir, J Saulière, Z Wang - Nature reviews Molecular cell biology, 2016 - nature.com
The exon junction complex (EJC) is deposited onto mRNAs following splicing and adopts a
unique structure, which can both stably bind to mRNAs and function as an anchor for diverse …

Maize polyubiquitin genes: structure, thermal perturbation of expression and transcript splicing, and promoter activity following transfer to protoplasts by …

AH Christensen, RA Sharrock, PH Quail - Plant molecular biology, 1992 - Springer
Two genomic clones (λUbi-1 and λUbi-2) encoding the highly conserved 76 amino acid
protein ubiquitin have been isolated from maize. Sequence analysis shows that both genes …

How introns influence and enhance eukaryotic gene expression

H Le Hir, A Nott, MJ Moore - Trends in biochemical sciences, 2003 - cell.com
Although it has been known since the late 1970s that intron-containing and intronless
versions of otherwise identical genes can exhibit dramatically different expression profiles …