Human development requires intricate cell specification and communication pathways that
allow an embryo to generate and appropriately connect more than 200 different cell types …

Inhibitor of DNA binding (ID) proteins are transcriptional regulators that control the timing of
cell fate determination and differentiation in stem and progenitor cells during normal …

Neurons in the central nervous system (CNS) lose their ability to regenerate early in
development, but the underlying mechanisms are unknown. By screening genes …

The identification of neurological symptoms caused by vitamin A deficiency pointed to a
critical, early developmental role of vitamin A and its metabolite, retinoic acid (RA). The …

The advent of induced pluripotent stem cell (iPSC)-derived neurons has revolutionized
Parkinson's disease (PD) research, but single-cell transcriptomic analysis suggests …

Inhibitors of DNA binding and cell differentiation (Id) proteins are members of the large
family of the helix-loop-helix (HLH) transcription factors, but they lack any DNA-binding motif …

Failure of axon regeneration after central nervous system (CNS) injuries results in
permanent functional deficits. Numerous studies in the past suggested that blocking …

The anaphase-promoting complex (APC/C) orchestrates progression through mitosis by
decorating cell-cycle regulators with ubiquitin chains. To nucleate chains, the APC/C links …

MYCN is a member of the MYC family of proto-oncogenes. It encodes a transcription factor,
MYCN, involved in the control of fundamental processes during embryonal development …

Postmitotic cell growth defines cell shape and size during development. However, the
mechanisms regulating postmitotic cell growth in plants remain unknown. Here we report the …