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Liquid-liquid phase separation in viral function
X Zhang, R Zheng, Z Li, J Ma - Journal of Molecular Biology, 2023 - Elsevier
An emerging set of results suggests that liquid-liquid phase separation (LLPS) is the basis
for the formation of membrane-less compartments in cells. Evidence is now mounting that …
for the formation of membrane-less compartments in cells. Evidence is now mounting that …
Control of viral latency by episome maintenance proteins
The human DNA tumor viruses Epstein–Barr virus (EBV), Kaposi's sarcoma-associated
herpesvirus (KSHV), and human papillomavirus (HPV) share the common property of …
herpesvirus (KSHV), and human papillomavirus (HPV) share the common property of …
Molecular mechanisms and cellular functions of liquid-liquid phase separation during antiviral immune responses
S Yang, W Shen, J Hu, S Cai, C Zhang, S **… - Frontiers in …, 2023 - frontiersin.org
Spatiotemporal separation of cellular components is vital to ensure biochemical processes.
Membrane-bound organelles such as mitochondria and nuclei play a major role in isolating …
Membrane-bound organelles such as mitochondria and nuclei play a major role in isolating …
Infection-induced epigenetic changes and their impact on the pathogenesis of diseases
N Fischer - Seminars in immunopathology, 2020 - Springer
Epigenetic modifications play a fundamental role in the regulation of cellular gene
expression. In addition to their role in mediating short-term responses, some epigenetic …
expression. In addition to their role in mediating short-term responses, some epigenetic …
Phase separation and DAXX redistribution contribute to LANA nuclear body and KSHV genome dynamics during latency and reactivation
O Vladimirova, A De Leo, Z Deng, A Wiedmer… - PLoS …, 2021 - journals.plos.org
Liquid-liquid phase separation (LLPS) can drive formation of diverse and essential
macromolecular structures, including those specified by viruses. Kaposi's Sarcoma …
macromolecular structures, including those specified by viruses. Kaposi's Sarcoma …
G-Quadruplexes in the regulation of viral gene expressions and their impacts on controlling infection
G-quadruplexes (G4s) are noncanonical nucleic acid structures that play significant roles in
regulating various biological processes, including replication, transcription, translation, and …
regulating various biological processes, including replication, transcription, translation, and …
Kaposi's sarcoma-associated herpesvirus (KSHV) LANA prevents KSHV episomes from degradation
K Nakajima, T Inagaki, JM Espera, Y Izumiya - Journal of Virology, 2024 - journals.asm.org
Protein knockdown with an inducible degradation system is a powerful tool for studying
proteins of interest in living cells. Here, we adopted the auxin-inducible degron (AID) …
proteins of interest in living cells. Here, we adopted the auxin-inducible degron (AID) …
Kaposi sarcoma-associated herpesvirus latency-associated nuclear antigen: More than a key mediator of viral persistence
TF Schulz, A Freise, SC Stein - Current Opinion in Virology, 2023 - Elsevier
Kaposi sarcoma-associated herpesvirus (KSHV), or human herpesvirus-8, is an oncogenic
herpesvirus. Its latency-associated nuclear antigen (LANA) is essential for the persistence of …
herpesvirus. Its latency-associated nuclear antigen (LANA) is essential for the persistence of …
LANA and hnRNP A1 Regulate the Translation of LANA mRNA through G-Quadruplexes
During the latent phase, Kaposi's sarcoma-associated herpes virus (KSHV) maintains itself
inside the host by esca** the host immune surveillance mechanism through restricted …
inside the host by esca** the host immune surveillance mechanism through restricted …
[HTML][HTML] Regulation of polyomavirus transcription by viral and cellular factors
JF Yang, J You - Viruses, 2020 - mdpi.com
Polyomavirus infection is widespread in the human population. This family of viruses
normally maintains latent infection within the host cell but can cause a range of human …
normally maintains latent infection within the host cell but can cause a range of human …