Liquid-liquid phase separation in viral function

X Zhang, R Zheng, Z Li, J Ma - Journal of Molecular Biology, 2023 - Elsevier
An emerging set of results suggests that liquid-liquid phase separation (LLPS) is the basis
for the formation of membrane-less compartments in cells. Evidence is now mounting that …

Control of viral latency by episome maintenance proteins

A De Leo, A Calderon, PM Lieberman - Trends in microbiology, 2020 - cell.com
The human DNA tumor viruses Epstein–Barr virus (EBV), Kaposi's sarcoma-associated
herpesvirus (KSHV), and human papillomavirus (HPV) share the common property of …

Molecular mechanisms and cellular functions of liquid-liquid phase separation during antiviral immune responses

S Yang, W Shen, J Hu, S Cai, C Zhang, S **… - Frontiers in …, 2023 - frontiersin.org
Spatiotemporal separation of cellular components is vital to ensure biochemical processes.
Membrane-bound organelles such as mitochondria and nuclei play a major role in isolating …

Infection-induced epigenetic changes and their impact on the pathogenesis of diseases

N Fischer - Seminars in immunopathology, 2020 - Springer
Epigenetic modifications play a fundamental role in the regulation of cellular gene
expression. In addition to their role in mediating short-term responses, some epigenetic …

Phase separation and DAXX redistribution contribute to LANA nuclear body and KSHV genome dynamics during latency and reactivation

O Vladimirova, A De Leo, Z Deng, A Wiedmer… - PLoS …, 2021 - journals.plos.org
Liquid-liquid phase separation (LLPS) can drive formation of diverse and essential
macromolecular structures, including those specified by viruses. Kaposi's Sarcoma …

G-Quadruplexes in the regulation of viral gene expressions and their impacts on controlling infection

AR Zareie, P Dabral, SC Verma - Pathogens, 2024 - mdpi.com
G-quadruplexes (G4s) are noncanonical nucleic acid structures that play significant roles in
regulating various biological processes, including replication, transcription, translation, and …

Kaposi's sarcoma-associated herpesvirus (KSHV) LANA prevents KSHV episomes from degradation

K Nakajima, T Inagaki, JM Espera, Y Izumiya - Journal of Virology, 2024 - journals.asm.org
Protein knockdown with an inducible degradation system is a powerful tool for studying
proteins of interest in living cells. Here, we adopted the auxin-inducible degron (AID) …

Kaposi sarcoma-associated herpesvirus latency-associated nuclear antigen: More than a key mediator of viral persistence

TF Schulz, A Freise, SC Stein - Current Opinion in Virology, 2023 - Elsevier
Kaposi sarcoma-associated herpesvirus (KSHV), or human herpesvirus-8, is an oncogenic
herpesvirus. Its latency-associated nuclear antigen (LANA) is essential for the persistence of …

LANA and hnRNP A1 Regulate the Translation of LANA mRNA through G-Quadruplexes

P Dabral, J Babu, A Zareie, SC Verma - Journal of virology, 2020 - journals.asm.org
During the latent phase, Kaposi's sarcoma-associated herpes virus (KSHV) maintains itself
inside the host by esca** the host immune surveillance mechanism through restricted …

[HTML][HTML] Regulation of polyomavirus transcription by viral and cellular factors

JF Yang, J You - Viruses, 2020 - mdpi.com
Polyomavirus infection is widespread in the human population. This family of viruses
normally maintains latent infection within the host cell but can cause a range of human …