The transcription factor p63 is a master regulator of epidermal development. Mutations in
p63 give rise to human developmental diseases that often manifest epidermal defects. In this …

The p53 protein family is the most studied protein family of all. Sequence analysis and
structure determination have revealed a high similarity of crucial domains between p53, p63 …

The genome-wide localization and function of endogenous Dnmt3a and Dnmt3b in adult
stem cells are unknown. Here, we show that in human epidermal stem cells, the two proteins …

Lung cancer is one of the most common cancer types worldwide and causes more than one
million deaths annually. Lung adenocarcinoma (AC) and lung squamous cell cancer (SCC) …

Background Open chromatin regions are correlated with active regulatory elements in
development and are dysregulated in diseases. The BAF (SWI/SNF) complex is essential for …

The p63 gene is a member of the p53/p63/p73 family of transcription factors and plays a
critical role in development and homeostasis of squamous epithelium. p63 is transcribed as …

The p53 transcription factor confers its potent tumor suppressor functions primarily through
the regulation of a large network of target genes. The recent explosion of next generation …

Squamous cell carcinoma (SCC) is an aggressive malignancy that can originate from
various organs. TP63 is a master regulator that plays an essential role in epidermal …

The lung exhibits a robust, multifaceted regenerative response to severe injuries such as
influenza infection, during which quiescent lung-resident epithelial progenitors participate in …

Purpose This review will discuss the role of vitamin D and calcium signaling in the epidermal
wound response with particular focus on the stem cells of the epidermis and hair follicle that …