In recent years an increasing number of publications have emphasized the growing
importance of hydrogen ion dynamics in modern cancer research, from etiopathogenesis …

The emergence of OpenAI's ChatGPT has put intense spotlight on Generative AI (Gen-AI)
systems and their possible impacts on Academic integrity. This paper provides an overview …

During the last few years, the understanding of the dysregulated hydrogen ion dynamics and
reversed proton gradient of cancer cells has resulted in a new and integral pH-centric …

LAMC2, as a unique chain in the Laminin 5 molecule, has been found to be associated with
malignant metastases in some cancers. However, the roles and mechanisms by which …

As a consequence of altered glucose metabolism, cancer cell intake is increased, producing
large amounts of lactate which is pumped out the cytosol by monocarboxylate transporters …

Abstract According to the World Health Organization, around 20% of all cancers would be
due to environmental factors. Among these factors, several chemicals are indeed well …

Background We have recently reported that the spinal angiotensin (Ang) converting enzyme
(ACE)/Ang II/AT1 receptor axis and downstream p38 MAPK phosphorylation are activated in …

Cancer cells generate protons (H+) that are extruded to the extracellular medium mainly via
the Na+/H+ exchanger 1 (NHE1), which regulates intracellular pH (pHi) and cell …

The treatment of cancer has been slowly but steadily progressing during the last fifty years.
Some tumors with a high mortality in the past are curable nowadays. However, there is one …

Despite all efforts, the treatment of breast cancer (BC) cannot be considered to be a success
story. The advances in surgery, chemotherapy and radiotherapy have not been sufficient at …