Mechanics and functional consequences of nuclear deformations
As the home of cellular genetic information, the nucleus has a critical role in determining cell
fate and function in response to various signals and stimuli. In addition to biochemical …
fate and function in response to various signals and stimuli. In addition to biochemical …
Lamina-associated domains: peripheral matters and internal affairs
At the nuclear periphery, associations of chromatin with the nuclear lamina through lamina-
associated domains (LADs) aid functional organization of the genome. We review the …
associated domains (LADs) aid functional organization of the genome. We review the …
[HTML][HTML] Nuclear lamins: Structure and function in mechanobiology
Nuclear lamins are type V intermediate filament proteins that polymerize into complex
filamentous meshworks at the nuclear periphery and in less structured forms throughout the …
filamentous meshworks at the nuclear periphery and in less structured forms throughout the …
A glance on the role of actin in osteogenic and adipogenic differentiation of mesenchymal stem cells
AU Khan, R Qu, T Fan, J Ouyang, J Dai - Stem cell research & therapy, 2020 - Springer
Mesenchymal stem cells (MSCs) have the capacity to differentiate into multiple lineages
including osteogenic and adipogenic lineages. An increasing number of studies have …
including osteogenic and adipogenic lineages. An increasing number of studies have …
A neuroligin isoform translated by circNlgn contributes to cardiac remodeling
Background: Fibrotic cardiac remodeling is a maladaptive response to acute or chronic
injury that leads to arrhythmia and progressive heart failure. The underlying mechanisms …
injury that leads to arrhythmia and progressive heart failure. The underlying mechanisms …
Depletion of lamins B1 and B2 promotes chromatin mobility and induces differential gene expression by a mesoscale-motion-dependent mechanism
Background B-type lamins are critical nuclear envelope proteins that interact with the three-
dimensional genomic architecture. However, identifying the direct roles of B-lamins on …
dimensional genomic architecture. However, identifying the direct roles of B-lamins on …
p53 regulates expression of nuclear envelope components in cancer cells
Nuclear organisation and architecture are essential for the maintenance of genomic integrity
as well as for the epigenetic regulations and gene expression. Disruption of lamin B1, major …
as well as for the epigenetic regulations and gene expression. Disruption of lamin B1, major …
Lamins as structural nuclear elements through evolution
Lamins are nuclear intermediate filament proteins with important, well-established roles in
humans and other vertebrates. Lamins interact with DNA and numerous proteins at the …
humans and other vertebrates. Lamins interact with DNA and numerous proteins at the …
The histone code of senescence
Senescence is the end point of a complex cellular response that proceeds through a set of
highly regulated steps. Initially, the permanent cell-cycle arrest that characterizes …
highly regulated steps. Initially, the permanent cell-cycle arrest that characterizes …
Nuclear lamin phosphorylation: an emerging role in gene regulation and pathogenesis of laminopathies
SY Liu, K Ikegami - Nucleus, 2020 - Taylor & Francis
Decades of studies have established that nuclear lamin polymers form the nuclear lamina, a
protein meshwork that supports the nuclear envelope structure and tethers heterochromatin …
protein meshwork that supports the nuclear envelope structure and tethers heterochromatin …