Evidence indicates that hypoxia and oxidative stress can control metabolic reprogramming
of cancer cells and other cells in tumor microenvironments and that the reprogrammed …

Phosphoglycerate kinase 1 (PGK1) is an essential enzyme in the aerobic glycolysis
pathway. PGK1 catalyzes the reversible transfer of a phosphate group from 1, 3 …

It is unclear how the Warburg effect that exemplifies enhanced glycolysis in the cytosol is
coordinated with suppressed mitochondrial pyruvate metabolism. We demonstrate here that …

Background Gallbladder cancer is the most common biliary tract malignancy and not
sensitive to chemotherapy. Autophagy is an important factor prolonging the survival of …

The PTEN tumor suppressor is frequently mutated or deleted in cancer and regulates
glucose metabolism through the PI3K-AKT pathway. However, whether PTEN directly …

Objective Pancreatic ductal adenocarcinoma (PDAC) is the most aggressive type of GI
tumour, and it possesses deregulated cellular energetics. Although recent advances in …

Peritoneal dissemination represents a devastating form of gastric cancer (GC) progression
with a dismal prognosis. There is no effective therapy for this condition. The 5-year survival …

Abstract Phosphoglycerate kinase 1 (PGK1) has complicated and multiple functions in
cancer occurrence, tumor progression and drug resistance. Sorafenib is the first-line …

Metabolic reprogramming has been demonstrated to have a significant impact on the
biological behaviors of tumor cells, among which glycolysis is an important form. Recent …

Metabolic reprogramming is a common hallmark of cancers and involves alterations in many
metabolic pathways during tumor initiation and progression. However, the cancer-specific …