Protein deamidation has been proposed to represent a “molecular clock” that progressively
disrupts protein structure and function in human degenerative diseases and natural aging …

Deamidation of asparagine and glutamine alters protein structures and affects the chemical
and biological properties of proteins. Protein deamidation has been demonstrated to be …

Common yet often overlooked, deamidation of peptidyl asparagine (Asn or N) generates
aspartic acid (Asp or D) or isoaspartic acid (isoAsp or isoD). Being a spontaneous, non …

Under the guideline issued by Food and Drug Administration (FDA), ANDAs for Certain
Highly Purified Synthetic Peptide Drug Products That Refer to Listed Drugs of rDNA Origin …

We describe preparation and use of the quaternary ammonium-based α-iodoacetamide
QDE and its isotopologue* QDE as reagents for chemoselective derivatization of cellular …

CIGB‐300 is a first‐in‐class synthetic peptide‐based drug of 25 amino acids currently
undergoing clinical trials in cancer patients. It contains an amidated disulfide cyclic …

The purpose of this study was to evaluate the effects of cyclodextrins (CyDs) to stabilize
exnatide in the microencapsulation medium and influence on the pharmaceutical properties …

Disulfide bond formation is critical for maintaining structure stability and function of many
peptides and proteins. Mass spectrometry has become an important tool for the elucidation …

During the production of recombinant proteins, misincorporation of Nva (norvaline) is
common and causes heterogeneity or even toxicity. To characterize Nva and differentiate it …

Isomeric amino acid residues such as valine (Val) and norvaline (Nva) are common in
recombinant proteins. The mis-incorporation of Nva for leucine (Leu) causes heterogeneity …