Metastatic prostate cancer

O Sartor, JS de Bono - New England Journal of Medicine, 2018 - Mass Medical Soc
Metastatic Prostate Cancer Interventions added to androgen-deprivation therapy in men with
metastatic prostate cancer have recently been noted to increase survival. Decisions about …

Machine learning and feature selection for drug response prediction in precision oncology applications

M Ali, T Aittokallio - Biophysical reviews, 2019 - Springer
In-depth modeling of the complex interplay among multiple omics data measured from
cancer cell lines or patient tumors is providing new opportunities toward identification of …

Key parameters of tumor epitope immunogenicity revealed through a consortium approach improve neoantigen prediction

DK Wells, MM van Buuren, KK Dang… - Cell, 2020 - cell.com
Many approaches to identify therapeutically relevant neoantigens couple tumor sequencing
with bioinformatic algorithms and inferred rules of tumor epitope immunogenicity. However …

CHAOS challenge-combined (CT-MR) healthy abdominal organ segmentation

AE Kavur, NS Gezer, M Barış, S Aslan, PH Conze… - Medical Image …, 2021 - Elsevier
Segmentation of abdominal organs has been a comprehensive, yet unresolved, research
field for many years. In the last decade, intensive developments in deep learning (DL) …

A community approach to mortality prediction in sepsis via gene expression analysis

TE Sweeney, TM Perumal, R Henao, M Nichols… - Nature …, 2018 - nature.com
Improved risk stratification and prognosis prediction in sepsis is a critical unmet need.
Clinical severity scores and available assays such as blood lactate reflect global illness …

A framework for validating AI in precision medicine: considerations from the European ITFoC consortium

R Tsopra, X Fernandez, C Luchinat… - BMC medical informatics …, 2021 - Springer
Background Artificial intelligence (AI) has the potential to transform our healthcare systems
significantly. New AI technologies based on machine learning approaches should play a key …

Integrating artificial and human intelligence: a partnership for responsible innovation in biomedical engineering and medicine

K Dzobo, S Adotey, NE Thomford… - Omics: a journal of …, 2020 - liebertpub.com
Historically, the term “artificial intelligence” dates to 1956 when it was first used in a
conference at Dartmouth College in the US. Since then, the development of artificial …

How to design preclinical studies in nanomedicine and cell therapy to maximize the prospects of clinical translation

JPA Ioannidis, BYS Kim, A Trounson - Nature biomedical engineering, 2018 - nature.com
The clinical translation of promising products, technologies and interventions from the
disciplines of nanomedicine and cell therapy has been slow and inefficient. In part …

Prostate cancer classification with multiparametric MRI transfer learning model

Y Yuan, W Qin, M Buyyounouski, B Ibragimov… - Medical …, 2019 - Wiley Online Library
Purpose Prostate cancer classification has a significant impact on the prognosis and
treatment planning of patients. Currently, this classification is based on the Gleason score …

Crowdsourcing in medical research: concepts and applications

JD Tucker, S Day, W Tang, B Bayus - PeerJ, 2019 - peerj.com
Crowdsourcing shifts medical research from a closed environment to an open collaboration
between the public and researchers. We define crowdsourcing as an approach to problem …