[HTML][HTML] α-Synuclein misfolding and Parkinson's disease
Substantial evidence links α-synuclein, a small highly conserved presynaptic protein with
unknown function, to both familial and sporadic Parkinson's disease (PD). α-Synuclein has …
unknown function, to both familial and sporadic Parkinson's disease (PD). α-Synuclein has …
Understanding protein non-folding
This review describes the family of intrinsically disordered proteins, members of which fail to
form rigid 3-D structures under physiological conditions, either along their entire lengths or …
form rigid 3-D structures under physiological conditions, either along their entire lengths or …
Natively unfolded proteins: a point where biology waits for physics
The experimental material accumulated in the literature on the conformational behavior of
intrinsically unstructured (natively unfolded) proteins was analyzed. Results of this analysis …
intrinsically unstructured (natively unfolded) proteins was analyzed. Results of this analysis …
Hydrodynamic radii of native and denatured proteins measured by pulse field gradient NMR techniques
Pulse field gradient NMR methods have been used to determine the effective hydrodynamic
radii of a range of native and nonnative protein conformations. From these experimental …
radii of a range of native and nonnative protein conformations. From these experimental …
Intrinsically disordered proteins from A to Z
The ideas that proteins might possess specific functions without being uniquely folded into
rigid 3D-structures and that these floppy polypeptides might constitute a noticeable part of …
rigid 3D-structures and that these floppy polypeptides might constitute a noticeable part of …
Carbonic anhydrase as a model for biophysical and physical-organic studies of proteins and protein− ligand binding
Carbonic anhydrase (CA, EC 4.2. 1.1) is a protein that is especially well-suited to serve as a
model in many types of studies in biophysics, bioanalysis, the physical-organic chemistry of …
model in many types of studies in biophysics, bioanalysis, the physical-organic chemistry of …
[HTML][HTML] α-Lactalbumin: structure and function
Small milk protein α-lactalbumin (α-LA), a component of lactose synthase, is a simple model
Ca2+ binding protein, which does not belong to the EF-hand proteins, and a classical …
Ca2+ binding protein, which does not belong to the EF-hand proteins, and a classical …
Design and Synthesis of a Water‐Stable Anionic Uranium‐Based Metal–Organic Framework (MOF) with Ultra Large Pores
Ionic metal–organic frameworks (MOFs) are a subclass of porous materials that have the
ability to incorporate different charged species in confined nanospace by ion‐exchange. To …
ability to incorporate different charged species in confined nanospace by ion‐exchange. To …
[PDF][PDF] Probing protein structure by limited proteolysis
Limited proteolysis experiments can be successfully used to probe conformational features
of proteins. In a number of studies it has been demonstrated that the sites of limited …
of proteins. In a number of studies it has been demonstrated that the sites of limited …
Intrinsically disordered proteins and their environment: effects of strong denaturants, temperature, pH, counter ions, membranes, binding partners, osmolytes, and …
Intrinsically disordered proteins (IDPs) differ from “normal” ordered proteins at several levels,
structural, functional and conformational. Amino acid biases characteristic for IDPs …
structural, functional and conformational. Amino acid biases characteristic for IDPs …