Genomic instability leads to mutations, cellular dysfunction and aberrant phenotypes at the
tissue and organism levels. A number of mechanisms have evolved to cope with …

Technical advances in the ability to measure mitochondrial dysfunction are providing new
insights into mitochondrial disease pathogenesis, along with new tools to objectively …

Oxidative stress is a phenotypic hallmark in several genetic disorders characterized by
cancer predisposition and/or propensity to premature ageing. Here we review the published …

Fanconi Anemia (FA) is a rare autosomal genetic disorder characterized by progressive
bone marrow failure (BMF), endocrine dysfunction, cancer, and other clinical features …

Werner syndrome (WS) is a premature aging disorder caused by mutations in a RecQ-like
DNA helicase. Mice lacking the helicase domain of the WRN homologue exhibit many …

Werner syndrome (WS) is a premature aging disorder caused by mutations in a RecQ-family
DNA helicase, WRN. Mice lacking part of the helicase domain of the WRN orthologue exhibit …

RECQL4 is a human RecQ helicase which is mutated in approximately two-thirds of
individuals with Rothmund–Thomson syndrome (RTS), a disease characterized at the …

This article describes the glutathione-triggered disassembly of gold nanocomposites
composed of gold cores and water-soluble copolymers [poly (Nn-isopropylacrylamide-co …

Werner Syndrome (WS) is a rare disorder characterized by the premature onset of a number
of age-related diseases. The gene responsible for WS encodes a DNA …

Werner syndrome (WS) is a premature aging disorder used as a model of normal human
aging. WS individuals have several characteristics of normal aging, such as cataracts, hair …