How to characterize the function of a brain region

S Genon, A Reid, R Langner, K Amunts… - Trends in cognitive …, 2018 - cell.com
Many brain regions have been defined, but a comprehensive formalization of each region's
function in relation to human behavior is still lacking. Current knowledge comes from various …

Cholinergic modulation of spatial learning, memory and navigation

N Solari, B Hangya - European Journal of Neuroscience, 2018 - Wiley Online Library
Spatial learning, including encoding and retrieval of spatial memories as well as holding
spatial information in working memory generally serving navigation under a broad range of …

Egocentric boundary vector tuning of the retrosplenial cortex

AS Alexander, LC Carstensen, JR Hinman… - Science …, 2020 - science.org
The retrosplenial cortex is reciprocally connected with multiple structures implicated in
spatial cognition, and damage to the region itself produces numerous spatial impairments …

Allocentric and egocentric spatial representations coexist in rodent medial entorhinal cortex

X Long, D Bush, B Deng, N Burgess… - Nature …, 2025 - nature.com
Successful navigation relies on reciprocal transformations between spatial representations
in world-centered (allocentric) and self-centered (egocentric) frames of reference. The …

The retrosplenial-parietal network and reference frame coordination for spatial navigation.

BJ Clark, CM Simmons, LE Berkowitz… - Behavioral …, 2018 - psycnet.apa.org
The retrosplenial cortex is anatomically positioned to integrate sensory, motor, and visual
information and is thought to have an important role in processing spatial information and …

What about “space” is important for episodic memory?

CL Fan, HM Sokolowski… - Wiley Interdisciplinary …, 2023 - Wiley Online Library
Early cognitive neuroscientific research revealed that the hippocampus is crucial for spatial
navigation in rodents, and for autobiographical episodic memory in humans. Researchers …

[HTML][HTML] The neuroscience of spatial navigation and the relationship to artificial intelligence

E Bermudez-Contreras, BJ Clark… - Frontiers in Computational …, 2020 - frontiersin.org
Recent advances in artificial intelligence (AI) and neuroscience are impressive. In AI, this
includes the development of computer programs that can beat a grandmaster at GO or …

Impaired hippocampal-cortical interactions during sleep in a mouse model of Alzheimer's disease

SD Cushing, I Skelin, SC Moseley, AC Stimmell… - Current Biology, 2020 - cell.com
Spatial learning is impaired in humans with preclinical Alzheimer's disease (AD). We
reported similar impairments in 3xTg-AD mice learning a spatial reorientation task. Memory …

Scalp recorded theta activity is modulated by reward, direction, and speed during virtual navigation in freely moving humans

MH Lin, O Liran, N Bauer, TE Baker - Scientific reports, 2022 - nature.com
Abstract Theta oscillations (~ 4–12 Hz) are dynamically modulated by speed and direction in
freely moving animals. However, due to the paucity of electrophysiological recordings of …

Using virtual global landmark to improve incidental spatial learning

J Liu, AK Singh, CT Lin - Scientific reports, 2022 - nature.com
To reduce the decline of spatial cognitive skills caused by the increasing use of automated
GPS navigation, the virtual global landmark (VGL) system is proposed to help people …