Fast-folding proteins have been a major focus of computational and experimental study
because they are accessible to both techniques: they are small and fast enough to be …

Equilibrium molecular dynamics simulations, in which proteins spontaneously and
repeatedly fold and unfold, have recently been used to help elucidate the mechanistic …

Translocation of proteins is correlated with structural fluctuations that access conformational
states higher in free energy than the folded state. We use electric fields at the solid-state …

Phosphorene, a monolayer of elemental phosphorus, has emerged as one of the most
significant two-dimensional (2D) atomic crystals in the post-graphene era, as a potential …

For the past two decades, protein folding experiments have been speeding up from the
second or millisecond time scale to the microsecond time scale, and full-atom simulations …

Using a newly developed microsecond pressure-jump apparatus, we monitor the refolding
kinetics of the helix-stabilized five-helix bundle protein λ* YA, the Y22W/Q33Y/G46, 48A …

The five-helix bundle λ-repressor fragment is a fast-folding protein. A length of 80 amino acid
residues puts it on the large end among all known microsecond folders, and its size poses a …

Inside the cell, proteins fold and perform complex functions through global structural
rearrangements. For proper function, they need to be at the brink of instability to be …

Because steric crowding is most effective when the crowding agent is similar in size to the
molecule that it acts upon and the average macromolecule inside cells is much larger than a …

Density is an easily adjusted variable in molecular dynamics (MD) simulations. Thus,
pressure-jump (P-jump)-induced protein refolding, if it could be made fast enough, would be …