The cancer treatment landscape has changed dramatically since the turn of the century,
resulting in substantial improvements in outcomes for patients. This Review summarizes …

It is accepted that the medicinal use of complex mixtures of plant-derived bioactive
compounds is more effective than purified bioactive compounds due to beneficial …

As next-generation artificial enzymes, nanozymes have shown great promise for tumor
catalytic therapy. In particular, their peroxidase-like activity has been employed to catalyze …

Combining existing drug therapy is essential in develo** new therapeutic agents in
disease prevention and treatment. In preclinical investigations, combined effect of certain …

Abstract Knowledge of therapeutic targets and early drug candidates is useful for improved
drug discovery. In particular, information about target regulators and the patented …

Covering: 2000 to 2019 According to a 2012 survey from the Centers for Disease Control
and Prevention, approximately 18% of the US population uses natural products (including …

Cancer therapies often have narrow therapeutic indexes and involve potentially suboptimal
combinations due to the dissimilar physical properties of drug molecules. Nanomedicine …

Drug combinations, offering increased therapeutic efficacy and reduced toxicity, play an
important role in treating multiple complex diseases. Yet, our ability to identify and validate …

Motivation Drug–target interaction (DTI) prediction is a foundational task for in-silico drug
discovery, which is costly and time-consuming due to the need of experimental search over …

Drug–drug interaction (DDI) prediction identifies interactions of drug combinations in which
the adverse side effects caused by the physicochemical incompatibility have attracted much …