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Current challenges and future opportunities of phage therapy
Antibiotic resistance is a major public health challenge worldwide, whose implications for
global health might be devastating if novel antibacterial strategies are not quickly …
global health might be devastating if novel antibacterial strategies are not quickly …
Understanding the complex phage-host interactions in biofilm communities
Bacteriophages and bacterial biofilms are widely present in natural environments, a fact that
has accelerated the evolution of phages and their bacterial hosts in these particular niches …
has accelerated the evolution of phages and their bacterial hosts in these particular niches …
Big impact of the tiny: bacteriophage–bacteria interactions in biofilms
Bacteriophages (phages) have been sha** bacterial ecology and evolution for millions of
years, for example, by selecting for defence strategies. Evidence supports that bacterial …
years, for example, by selecting for defence strategies. Evidence supports that bacterial …
Bacterial multicellular behavior in antiviral defense
T Luthe, L Kever, K Thormann, J Frunzke - Current Opinion in Microbiology, 2023 - Elsevier
Highlights•Bacterial multicellular behavior plays an important role in predatory
interactions.•Small molecules in signaling or chemical defense contribute to phage …
interactions.•Small molecules in signaling or chemical defense contribute to phage …
A growing microcolony can survive and support persistent propagation of virulent phages
Bacteria form colonies and secrete extracellular polymeric substances that surround the
individual cells. These spatial structures are often associated with collaboration and quorum …
individual cells. These spatial structures are often associated with collaboration and quorum …
How good are bacteriophages as an alternative therapy to mitigate biofilms of nosocomial infections
Bacteria survive on any surface through the generation of biofilms that provide a protective
environment to grow as well as making them drug resistant. Extracellular polymeric matrix is …
environment to grow as well as making them drug resistant. Extracellular polymeric matrix is …
Phage-bacterial dynamics with spatial structure: self organization around phage sinks can promote increased cell densities
Bacteria growing on surfaces appear to be profoundly more resistant to control by lytic
bacteriophages than do the same cells grown in liquid. Here, we use simulation models to …
bacteriophages than do the same cells grown in liquid. Here, we use simulation models to …
Environmental structure drives resistance to phages and antibiotics during phage therapy and to invading lysogens during colonisation
Microbial communities are shaped by bacteriophages through predation and lysogeny. A
better understanding of the interactions between these processes across different types of …
better understanding of the interactions between these processes across different types of …
Sustainability of spatially distributed bacteria-phage systems
Virulent phages can expose their bacterial hosts to devastating epidemics, in principle
leading to complete elimination of their hosts. Although experiments indeed confirm a large …
leading to complete elimination of their hosts. Although experiments indeed confirm a large …
Bottom-up biofilm eradication using bacteriophage-loaded magnetic nanocomposites: a computational and experimental study
Biofilms cause a variety of pervasive problems in water treatment, distribution and reuse
systems that are difficult to mitigate due to their resistance to disinfectants. We used …
systems that are difficult to mitigate due to their resistance to disinfectants. We used …