Current challenges and future opportunities of phage therapy

DP Pires, AR Costa, G Pinto, L Meneses… - FEMS microbiology …, 2020 - academic.oup.com
Antibiotic resistance is a major public health challenge worldwide, whose implications for
global health might be devastating if novel antibacterial strategies are not quickly …

Understanding the complex phage-host interactions in biofilm communities

DP Pires, LDR Melo, J Azeredo - Annual Review of Virology, 2021 - annualreviews.org
Bacteriophages and bacterial biofilms are widely present in natural environments, a fact that
has accelerated the evolution of phages and their bacterial hosts in these particular niches …

Big impact of the tiny: bacteriophage–bacteria interactions in biofilms

MF Hansen, SL Svenningsen, HL Røder… - Trends in …, 2019 - cell.com
Bacteriophages (phages) have been sha** bacterial ecology and evolution for millions of
years, for example, by selecting for defence strategies. Evidence supports that bacterial …

Bacterial multicellular behavior in antiviral defense

T Luthe, L Kever, K Thormann, J Frunzke - Current Opinion in Microbiology, 2023 - Elsevier
Highlights•Bacterial multicellular behavior plays an important role in predatory
interactions.•Small molecules in signaling or chemical defense contribute to phage …

A growing microcolony can survive and support persistent propagation of virulent phages

RS Eriksen, SL Svenningsen, K Sneppen… - Proceedings of the …, 2018 - pnas.org
Bacteria form colonies and secrete extracellular polymeric substances that surround the
individual cells. These spatial structures are often associated with collaboration and quorum …

How good are bacteriophages as an alternative therapy to mitigate biofilms of nosocomial infections

A Singh, S Padmesh, M Dwivedi… - Infection and Drug …, 2022 - Taylor & Francis
Bacteria survive on any surface through the generation of biofilms that provide a protective
environment to grow as well as making them drug resistant. Extracellular polymeric matrix is …

Phage-bacterial dynamics with spatial structure: self organization around phage sinks can promote increased cell densities

JJ Bull, KA Christensen, C Scott, BR Jack, CJ Crandall… - Antibiotics, 2018 - mdpi.com
Bacteria growing on surfaces appear to be profoundly more resistant to control by lytic
bacteriophages than do the same cells grown in liquid. Here, we use simulation models to …

Environmental structure drives resistance to phages and antibiotics during phage therapy and to invading lysogens during colonisation

JAM Sousa, EPC Rocha - Scientific reports, 2019 - nature.com
Microbial communities are shaped by bacteriophages through predation and lysogeny. A
better understanding of the interactions between these processes across different types of …

Sustainability of spatially distributed bacteria-phage systems

RS Eriksen, N Mitarai, K Sneppen - Scientific reports, 2020 - nature.com
Virulent phages can expose their bacterial hosts to devastating epidemics, in principle
leading to complete elimination of their hosts. Although experiments indeed confirm a large …

Bottom-up biofilm eradication using bacteriophage-loaded magnetic nanocomposites: a computational and experimental study

P Yu, Z Wang, M Marcos-Hernandez, P Zuo… - Environmental …, 2019 - pubs.rsc.org
Biofilms cause a variety of pervasive problems in water treatment, distribution and reuse
systems that are difficult to mitigate due to their resistance to disinfectants. We used …