Ozone therapy has been widely used in everyday clinical practice over the last few years,
leading to significant clinical results in the treatment of herniated discs and pain …

Despite massive investments in drug research and development, the significant decline in
the number of new drugs approved or translated to clinical use raises the question, whether …

Emerging evidence has highlighted the host immune system in modulating the patient
response to chemotherapy, but the mechanism of this modulation remains unclear. The aim …

Enhanced sensitivity to Wnts is an emerging hallmark of a subset of cancers, defined in part
by mutations regulating the abundance of their receptors. Whether these mutations identify a …

Transcriptomic analyses have identified tens of thousands of intergenic, intronic, and cis-
antisense long noncoding RNAs (lncRNAs) that are expressed from mammalian genomes …

Overnutrition disrupts circadian metabolic rhythms by mechanisms that are not well
understood. Here, we show that diet-induced obesity (DIO) causes massive remodeling of …

Breast cancer metastasis remains a clinical challenge, even within a single patient across
multiple sites of the disease. Genome-wide comparisons of both the DNA and gene …

In order to engineer safer nanomaterials, there is a need to understand, systematically
evaluate, and develop constructs with appropriate cellular uptake and intracellular fates. The …

Enteroendocrine cells (EEs) are interspersed between enterocytes and stem cells in the
Drosophila intestinal epithelium. Like enterocytes, EEs express components of the immune …

The oncogenic phenotype is complex, resulting from the accumulation of multiple somatic
mutations that lead to the deregulation of growth regulatory and cell fate controlling activities …