The past decade has witnessed significant advances in the systemic treatment of advanced
hepatocellular carcinoma (HCC). Nevertheless, the newly developed treatment strategies …

Tumor-associated macrophages (TAMs) are pivotal in cancer progression, influencing tumor
growth, angiogenesis, and immune evasion. This review explores the spatial and temporal …

Lactate plays a critical role as an energy substrate, metabolite, and signaling molecule in
hepatocellular carcinoma (HCC). Intracellular lactate‐derived protein lysine lactylation (Kla) …

Immune-checkpoint inhibitors (ICIs) are now widely used for the treatment of patients with
advanced-stage hepatocellular carcinoma (HCC). Two different ICI-containing regimens …

Mammalian innate-like T cells (ILTCs), including mucosal-associated invariant T (MAIT),
natural killer T (NKT), and γδ T cells, are abundant tissue-resident lymphocytes that have …

Hepatocellular carcinoma (HCC) frequently recurs from minimal residual disease (MRD),
which persists after therapy. Here, we identified mechanisms of persistence of residual …

Cancer and metabolic disorders have emerged as major global health challenges, reaching
epidemic levels in recent decades. Often viewed as separate issues, metabolic disorders …

Heavy alcohol intake induces a wide spectrum of liver diseases ranging from steatosis,
steatohepatitis, cirrhosis, and HCC. Although alcohol consumption is a well-known risk …

Hepatocellular carcinoma (HCC) is a highly frequent malignancy worldwide. The occurrence
and progression of HCC is a complex process closely related to the polarization of tumor …

Liver cancer is a major global health concern, ranking among the top causes of cancer-
related deaths worldwide. Despite advances in medical research, the prognosis for liver …