[HTML][HTML] Pathophysiology and therapeutic approaches for spinal cord injury

R Lima, A Monteiro, AJ Salgado, S Monteiro… - International Journal of …, 2022 - mdpi.com
Spinal cord injury (SCI) is a disabling condition that disrupts motor, sensory, and autonomic
functions. Despite extensive research in the last decades, SCI continues to be a global …

A comprehensive look at the psychoneuroimmunoendocrinology of spinal cord injury and its progression: mechanisms and clinical opportunities

MA Ortega, O Fraile-Martinez, C García-Montero… - Military Medical …, 2023 - Springer
Spinal cord injury (SCI) is a devastating and disabling medical condition generally caused
by a traumatic event (primary injury). This initial trauma is accompanied by a set of biological …

[HTML][HTML] Functional hydrogels as therapeutic tools for spinal cord injury: New perspectives on immunopharmacological interventions

CM Walsh, JK Wychowaniec, DF Brougham… - Pharmacology & …, 2022 - Elsevier
Spinal cord injury (SCI) is a complex medical and psychological challenge for which there is
no curative therapy currently available. Despite major progress in pharmacological and …

Filling the gap: neural stem cells as a promising therapy for spinal cord injury

IM Pereira, A Marote, AJ Salgado, NA Silva - Pharmaceuticals, 2019 - mdpi.com
Spinal cord injury (SCI) can lead to severe motor, sensory and social impairments having a
huge impact on patients' lives. The complex and time-dependent SCI pathophysiology has …

Recent advances in the regenerative approaches for traumatic spinal cord injury: materials perspective

WA Abbas, ME Ibrahim, M El-Naggar… - ACS Biomaterials …, 2020 - ACS Publications
Spinal cord injury (SCI) is a devastating health condition that may lead to permanent
disabilities and death. Understanding the pathophysiological perspectives of traumatic SCI …

Neurotrauma—From injury to repair: Clinical perspectives, cellular mechanisms and promoting regeneration of the injured brain and spinal cord

AR Stevens, A Belli, Z Ahmed - Biomedicines, 2024 - mdpi.com
Traumatic injury to the brain and spinal cord (neurotrauma) is a common event across
populations and often causes profound and irreversible disability. Pathophysiological …

[HTML][HTML] A therapeutic matrix: virtual reality as a clinical tool for spinal cord injury-induced neuropathic pain

E Leemhuis, V Giuffrida, AM Giannini, M Pazzaglia - Brain sciences, 2021 - mdpi.com
Neuropathic pain (NP) is a chronic, debilitating, and resistant form of pain. The onset rate of
NP following spinal cord injuries (SCI) is high and may reduce the quality of life more than …

Chronic pain after spinal cord injury: is there a role for neuron-immune dysregulation?

SS Chambel, I Tavares, CD Cruz - Frontiers in Physiology, 2020 - frontiersin.org
Spinal cord injury (SCI) is a devastating event with a tremendous impact in the life of the
affected individual and family. Traumatic injuries related to motor vehicle accidents, falls …

Pre-clinical assessment of roflumilast Therapy in a thoracic model of Spinal cord Injury

CS Sousa, R Lima, JR Cibrão, ED Gomes… - Pharmaceutics, 2023 - mdpi.com
The failure of axons to regenerate after a spinal cord injury (SCI) remains one of the greatest
challenges in neuroscience. The initial mechanical trauma is followed by a secondary injury …

The secretome of macrophages has a differential impact on spinal cord injury recovery according to the polarization protocol

J Lentilhas-Graça, DJ Santos, J Afonso… - Frontiers in …, 2024 - frontiersin.org
Introduction The inflammatory response after spinal cord injury (SCI) is an important
contributor to secondary damage. Infiltrating macrophages can acquire a spectrum of …