Abstract G-quadruplexes (G4s) are non-canonical nucleic acids secondary structures that
form within guanine-rich strands of regulatory genomic regions. G4s have been extensively …

Abstract G-quadruplexes (G4s) are non-classical DNA or RNA secondary structures that
have been first observed decades ago. Over the years, these four-stranded structural motifs …

Abstract i-Motifs (iMs) are four-stranded DNA structures that form at cytosine (C)-rich
sequences in acidic conditions in vitro. Their formation in cells is still under debate. We …

Genomic maps of DNA G-quadruplexes (G4s) can help elucidate the roles that these
secondary structures play in various organisms. Herein, we employ an improved version of a …

Progress in the design of G-quadruplex (G4) binding ligands relies on the availability of
approaches that assess the binding mode and nature of the interactions between G4 …

Guanine-rich DNA sequences can fold into stable four-stranded structures called G-
quadruplexes or G4s. Research in the past decade demonstrated that G4 structures are …

G-quadruplexes are non-canonical nucleic-acid structures that control transcription,
replication, and recombination in organisms. G-quadruplexes are present in eukaryotes …

Mycobacterium tuberculosis, the bacterium responsible for tuberculosis, is one of the most
successful pathogens in human history. An extremely resilient cell wall and highly evolved …

ABSTRACT DNA strands consisting of multiple runs of guanines can adopt a noncanonical,
four-stranded DNA secondary structure known as G-quadruplex or G4 DNA. G4 DNA is …

Organic small molecules that can recognize and bind to G-quadruplex and i-Motif nucleic
acids have great potential as selective drugs or as tools in drug target discovery programs …