Amyotrophic lateral sclerosis (ALS) is a devastating disease caused by degeneration of
motor neurons. As with all major neurodegenerative disorders, development of disease …

Microglia activation is observed in various neurodegenerative diseases. Recent advances in
single-cell technologies have revealed that these reactive microglia were with high spatial …

The human gastrointestinal tract is populated with a diverse microbial community. The vast
genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every …

Microglia are mononuclear phagocytes of mesodermal origin that migrate to the central
nervous system (CNS) during the early stages of embryonic development. After colonizing …

Brain aging is a recognized risk factor for neurodegenerative diseases like Alzheimer's
disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS, Lou Gehrig's …

The prevailing motor neuron-centric view of amyotrophic lateral sclerosis (ALS)
pathogenesis could be an important factor in the failure to identify disease-modifying therapy …

Transactive response DNA-binding protein-43 (TDP-43) is an RNA/DNA binding protein that
forms phosphorylated and ubiquitinated aggregates in the cytoplasm of motor neurons in …

Background Amyotrophic lateral sclerosis (ALS) is a multifactorial neurodegenerative
disease characterised by the loss of upper and lower motor neurons. Increasing evidence …

Tauopathies are a heterogenous class of diseases characterized by cellular accumulation of
aggregated tau and include diseases such as Alzheimer's disease (AD), progressive …

Frontotemporal dementia is clinically and neuropathologically heterogeneous, but
neuroinflammation, atrophy and cognitive impairment occur in all of its principal syndromes …