The N‐end rule pathway and regulation by proteolysis
A Varshavsky - Protein science, 2011 - Wiley Online Library
The N‐end rule relates the regulation of the in vivo half‐life of a protein to the identity of its N‐
terminal residue. Degradation signals (degrons) that are targeted by the N‐end rule pathway …
terminal residue. Degradation signals (degrons) that are targeted by the N‐end rule pathway …
Recent developments in amide synthesis using nonactivated starting materials
Amides are unquestionably one of the most important functional groups in organic chemistry
because of their presence in numerous interesting molecules such as peptides …
because of their presence in numerous interesting molecules such as peptides …
The N-end rule pathway
The N-end rule pathway is a proteolytic system in which N-terminal residues of short-lived
proteins are recognized by recognition components (N-recognins) as essential components …
proteins are recognized by recognition components (N-recognins) as essential components …
Structural perspective of peptidoglycan biosynthesis and assembly
AL Lovering, SS Safadi… - Annual review of …, 2012 - annualreviews.org
The peptidoglycan biosynthetic pathway is a critical process in the bacterial cell and is
exploited as a target for the design of antibiotics. This pathway culminates in the production …
exploited as a target for the design of antibiotics. This pathway culminates in the production …
Adapting the machine: adaptor proteins for Hsp100/Clp and AAA+ proteases
Members of the AAA+ protein superfamily contribute to many diverse aspects of protein
homeostasis in prokaryotic cells. As a fundamental component of numerous proteolytic …
homeostasis in prokaryotic cells. As a fundamental component of numerous proteolytic …
The N-end rule pathway: emerging functions and molecular principles of substrate recognition
SM Sriram, BY Kim, YT Kwon - Nature reviews Molecular cell biology, 2011 - nature.com
The N-end rule defines the protein-destabilizing activity of a given amino-terminal residue
and its post-translational modification. Since its discovery 25 years ago, the pathway …
and its post-translational modification. Since its discovery 25 years ago, the pathway …
Cyclodipeptide synthases are a family of tRNA-dependent peptide bond–forming enzymes
Cyclodipeptides and their derivatives belong to the diketopiperazine (DKP) family, which is
comprised of a broad array of natural products that exhibit useful biological properties. In the …
comprised of a broad array of natural products that exhibit useful biological properties. In the …
The nonribosomal synthesis of diketopiperazines in tRNA-dependent cyclodipeptide synthase pathways
Covering: up to 2012 We review here work on the biosynthesis of diketopiperazines (DKPs),
a large class of natural products with noteworthy biological activities, focusing on the …
a large class of natural products with noteworthy biological activities, focusing on the …
Sodium methoxide: a simple but highly efficient catalyst for the direct amidation of esters
T Ohshima, Y Hayashi, K Agura, Y Fujii… - Chemical …, 2012 - pubs.rsc.org
Sodium methoxide : a simple but highly efficient catalyst for the direct amidation of esters -
Chemical Communications (RSC Publishing) DOI:10.1039/C2CC32153J Royal Society of …
Chemical Communications (RSC Publishing) DOI:10.1039/C2CC32153J Royal Society of …
A paralog of lysyl-tRNA synthetase aminoacylates a conserved lysine residue in translation elongation factor P
T Yanagisawa, T Sumida, R Ishii, C Takemoto… - Nature structural & …, 2010 - nature.com
Aminoacyl-tRNA synthetase (aaRS) paralogs with unknown functions exist in various
species. We now report novel'protein lysylation'by an Escherichia coli lysyl-tRNA synthetase …
species. We now report novel'protein lysylation'by an Escherichia coli lysyl-tRNA synthetase …