In this review, synthetic and mechanistic aspects of key methodologies that exploit C–C
single-bond cleavage of strained ring systems are highlighted. The focus is on transition …

Transition metal (TM)‐catalyzed difunctionalization of unactivated olefins with two carbon‐
based entities is a powerful method to construct complex molecular architectures rapidly …

Conspectus Bridged and fused rings are commonly found in biologically important
molecules. Current tactics to construct these ring systems are primarily based on stepwise …

London dispersion (LD) interactions are the main contribution of the attractive part of the van
der Waals potential. Even though LD effects are the driving force for molecular aggregation …

The transition-metal-catalyzed “cut and sew” transformation has recently emerged as a
useful strategy for preparing complex molecular structures. After oxidative addition of a …

A special type of C–H functionalization can be achieved through C–H insertion combined
with Cope rearrangement (CHCR) in the presence of dirhodium catalysts. This type of …

The current understanding of ligand effects in transition metal catalysis is mostly based on
the analysis of catalyst–substrate through-bond and through-space interactions, with the …

C− C bond activation has emerged as an increasingly useful approach for constructing
complex molecular scaffolds through unusual bond-disconnection strategies. As a common …

We describe an open-source computational toolkit (AARON: An Automated Reaction
Optimizer for New catalysts) that automates the quantum mechanical geometry optimization …

An asymmetric 1, 2-dicarbofunctionalization of unactivated alkenes with aryl iodides and
aryl/alkenylboronic esters under nickel/bioxazoline catalysis is disclosed. A wide array of …