Humoral immunity depends on the germinal centre (GC) reaction during which somatically
mutated high-affinity memory B cells and plasma cells are generated. Recent studies have …

MicroRNAs (miRNAs) are crucial post-transcriptional regulators of haematopoietic cell fate
decisions. They act by negatively regulating the expression of key immune development …

Primary central nervous system lymphomas (PCNSLs) and primary testicular lymphomas
(PTLs) are extranodal large B-cell lymphomas (LBCLs) with inferior responses to current …

Chronic hepatitis C virus (HCV) infection with advanced cirrhosis or post‐liver
transplantation recurrence represents a high unmet medical need with no approved …

Extracellular vesicles (EVs) and their cargo microRNAs (miRNAs) are important regulators of
embryo development to the blastocyst stage and beyond. Before implantation can take …

MicroRNAs (miRNAs) play a critical role in regulation of tumor metastasis. However, the role
of these molecules in hepatocellular carcinoma (HCC) has not been fully elucidated. In this …

Autoimmune Addison's disease (AAD) is characterized by the autoimmune destruction of the
adrenal cortex. Low prevalence and complex inheritance have long hindered successful …

It is well acknowledged that immune system is deeply involved in cancer initiation and
progression, and can exert both pro-tumorigenic and anti-tumorigenic effects, depending on …

Autoimmune Addison disease is an endocrinopathy that is fatal if not diagnosed and treated
in a timely manner. Its rarity has hampered unbiased studies of the predisposing genetic …

T cell exhaustion is a state of T cell dysfunction that arises during many cancer. miRNAs are
one of major gene regulators which result in translational inhibition and/or mRNA …