Sharp wave ripples (SPW‐Rs) represent the most synchronous population pattern in the
mammalian brain. Their excitatory output affects a wide area of the cortex and several …

Acetylcholine in the brain alters neuronal excitability, influences synaptic transmission,
induces synaptic plasticity, and coordinates firing of groups of neurons. As a result, it …

Molecular diversity of microglia, the resident immune cells in the CNS, is reported. Whether
microglial subsets characterized by the expression of specific proteins constitute subtypes …

Alzheimer's disease (AD) is the most common cause of dementia worldwide. The etiology is
multifactorial, and pathophysiology of the disease is complex. Data indicate an exponential …

This review focuses on the neuronal and circuit mechanisms involved in the generation of
the theta (θ) rhythm and of its participation in behavior. Data have accumulated indicating …

Until recently, clinicians and researchers have performed gait assessments and cognitive
assessments separately when evaluating older adults, but increasing evidence from clinical …

Classical Hebbian learning puts the emphasis on joint pre-and postsynaptic activity, but
neglects the potential role of neuromodulators. Since neuromodulators convey information …

Noradrenergic and cholinergic systems are among the most vulnerable brain systems in
neuropsychiatric diseases of ageing, including Alzheimer's disease, Parkinson's disease …

Alzheimer's disease (AD) is a progressive neurodegenerative disease, characterized by the
loss of memory, multiple cognitive impairments and changes in the personality and …

This review describes the preclinical mechanisms that may underlie the increased
therapeutic benefit of combination therapy—with the N-methyl-d-aspartate receptor …