N-methyl-D-aspartate (NMDA) receptor antagonists such as phencyclidine (PCP),
dizocilpine (MK-801) and ketamine have long been considered a model of schizophrenia …

OBJECTIVE: The clinical hallmark of schizophrenia is psychosis. The objective of this
overview is to link the neurobiology (brain), the phenomenological experience (mind), and …

Rationale: Since the mid-1970s, cross-species translational studies of prepulse inhibition
(PPI) have increased at an astounding pace as the value of this neurobiologically …

The startle response is composed by a set of reflex behaviors intended to prepare the
organism to face a potentially relevant stimulus. This response can be modulated by several …

Retrospective studies in humans suggest that chronic maternal stress during pregnancy,
associated with raised plasma levels of CRH, ACTH and cortisol may increase the likelihood …

Abstract The serotonin-2A receptor (5-HT 2A R) has been implicated in the pathogenesis of
schizophrenia and related inhibitory gating and behavioral inhibition deficits of …

d-Lysergic Acid Diethylamide (LSD) is known for its hallucinogenic properties and psychotic-
like symptoms, especially at high doses. It is indeed used as a pharmacological model of …

Objective: The authors used a custom array of 1,536 single-nucleotide polymorphisms
(SNPs) to interrogate 94 functionally relevant candidate genes for schizophrenia and identify …

Context Patients with schizophrenia exhibit deficits in automatic, preattentive sensorimotor
gating (prepulse inhibition [PPI]) of the startle reflex. Objective To assess the relationships …

Prepulse inhibition (PPI) is the attenuation of the startle reflex when the sudden intense
startling stimulus is shortly preceded by a weaker, non-startling sensory stimulus (prepulse) …