Reactive oxygen species (ROS) are normal products of a number of biochemical reactions
and are important signaling molecules. However, at the same time, they are toxic to cells …

B cell acute lymphoblastic leukemia (B-ALL) arises from genetic alterations impacting B cell
progenitors, ultimately leading to clinically overt disease. Extensive collaborative efforts in …

Abstract Paraoxonase 2 (PON2) is a multifunctional intracellular enzyme that has received
growing attention for its ability to modulate various aspects of normal and malignant cellular …

Paraoxonase-2 (PON2) is a ubiquitously expressed intracellular protein that is localized in
the perinuclear region, the endoplasmic reticulum (ER), and mitochondria, and is also …

Angioimmunoblastic T-cell lymphoma (AITL) is a malignant hematologic tumor arising from T
follicular helper (Tfh) cells. High-throughput genomic sequencing studies have shown that …

Clear cell renal cell carcinoma (ccRCC) represents the most common subtype of renal
tumor. Despite recent advances in identifying novel target molecules, the prognosis of …

Objectives The high frequency of chemotherapy resistance is ultimately responsible for
clinical relapse in acute lymphoblastic leukemia (ALL). Nevertheless, the molecular …

Background High-dimensional datasets with low sample sizes (HDLSS) are pivotal in the
fields of biology and bioinformatics. One of core objective of HDLSS is to select most …

The mammalian paraoxonases (PONs) have been linked to protection against oxidative
stress. However, the physiological roles of members in this family (PON1, PON2, and PON3) …

Acute lymphoblastic leukemia (ALL), a remarkable cancer that mainly affects children, has
seen commendable advances in its treatment. However, the occurrence of relapses after …