Cancer the 'RBP'eutics–RNA-binding proteins as therapeutic targets for cancer

S Mohibi, X Chen, J Zhang - Pharmacology & therapeutics, 2019 - Elsevier
RNA-binding proteins (RBPs) play a critical role in the regulation of various RNA processes,
including splicing, cleavage and polyadenylation, transport, translation and degradation of …

[HTML][HTML] RNA binding proteins (RBPs) and their role in DNA damage and radiation response in cancer

M Mehta, R Raguraman, R Ramesh… - Advanced drug delivery …, 2022 - Elsevier
Traditionally majority of eukaryotic gene expression is influenced by transcriptional and post-
transcriptional events. Alterations in the expression of proteins that act post-transcriptionally …

[HTML][HTML] Voltage-gated calcium channels: Novel targets for cancer therapy

NN Phan, CY Wang, CF Chen, Z Sun… - Oncology …, 2017 - spandidos-publications.com
Voltage-gated calcium channels (VGCCs) comprise five subtypes: The L‑type; R‑type; N‑
type; P/Q‑type; and T‑type, which are encoded by α1 subunit genes. Calcium ion channels …

CDK9 keeps RNA polymerase II on track

S Egloff - Cellular and Molecular Life Sciences, 2021 - Springer
Abstract Cyclin-dependent kinase 9 (CDK9), the kinase component of positive transcription
elongation factor b (P-TEFb), is essential for transcription of most protein-coding genes by …

The La and related RNA‐binding proteins (LARPs): structures, functions, and evolving perspectives

RJ Maraia, S Mattijssen… - Wiley Interdisciplinary …, 2017 - Wiley Online Library
La was first identified as a polypeptide component of ribonucleic protein complexes targeted
by antibodies in autoimmune patients and is now known to be a eukaryote cell‐ubiquitous …

7SK snRNA: a noncoding RNA that plays a major role in regulating eukaryotic transcription

BM Peterlin, JE Brogie, DH Price - Wiley Interdisciplinary …, 2012 - Wiley Online Library
The human 7SK small nuclear RNA (snRNA) is an abundant noncoding RNA whose
function has been conserved in evolution from invertebrates to humans. It is transcribed by …

Mitosis is a source of potential markers for screening and survival and therapeutic targets in cervical cancer

AM Espinosa, A Alfaro, E Roman-Basaure… - PloS one, 2013 - journals.plos.org
The effect of preventive human papillomavirus (HPV) vaccination on the reduction of the
cervical cancer (CC) burden will not be known for 30 years. Therefore, it's still necessary to …

LARP1 post-transcriptionally regulates mTOR and contributes to cancer progression

M Mura, TG Hopkins, T Michael, N Abd-Latip, J Weir… - Oncogene, 2015 - nature.com
RNA-binding proteins (RBPs) bind to and post-transcriptionally regulate the stability of
mRNAs. La-related protein 1 (LARP1) is a conserved RBP that interacts with poly-A-binding …

SRSF10-mediated IL1RAP alternative splicing regulates cervical cancer oncogenesis via mIL1RAP-NF-κB-CD47 axis

F Liu, M Dai, Q Xu, X Zhu, Y Zhou, S Jiang, Y Wang… - Oncogene, 2018 - nature.com
High-risk human papillomavirus oncoproteins E6 and E7 are the major etiological factors of
cervical cancer but are insufficient for malignant transformation of cervical cancer …

Comprehensive functional characterization of cancer–testis antigens defines obligate participation in multiple hallmarks of cancer

KE Maxfield, PJ Taus, K Corcoran, J Wooten… - Nature …, 2015 - nature.com
Tumours frequently activate genes whose expression is otherwise biased to the testis,
collectively known as cancer–testis antigens (CTAs). The extent to which CTA expression …