Objective We previously implicated the lipid mediator lysophosphatidic acid (LPA) as having
a role in dermal fibrosis in systemic sclerosis (SSc). The aim of this study was to identify the …

Fewer than half of patients with systemic sclerosis demonstrate modified Rodnan skin score
improvement during mycophenolate mofetil (MMF) treatment. To understand the molecular …

Autoantibodies (Aabs) are frequent in systemic sclerosis (SSc). Although recognized as
potent biomarkers, their pathogenic role is debated. This study explored the effect of purified …

Objective Although physical therapy can help preserve mobility in patients with systemic
sclerosis (SSc), stretching has not been used systematically as a treatment to prevent or …

The article focuses on the study related to fibrosis which is the replacement of healthy tissue
by an excessive deposition of extracellular matrix. It mentions that scarring and tissue …

Systemic sclerosis occurs in children and has similarities to the adult disease, but also
distinct differences. In particular, the patterns of skin sclerosis are less consistent and more …

Systemic sclerosis (SSc) is a complex autoimmune disease involving the immune system,
vasculature and extracellular matrix. Dysregulation of the Wnt pathway has been implicated …

Systemic sclerosis (SSc) is a rare systemic autoimmune disease characterized by fibrosis of
the skin and internal organs. Alternatively-activated/pro-fibrotic macrophages (M2) have …

Scleroderma (SSc) is a heterogeneous, progressive disease characterized by collagen
accumulation in skin. The majority of the patients with this condition present with debilitating …

Abstract Overview: The tight skin 2 (Tsk2/+) mouse is a genetic model of systemic sclerosis
(SSc). This model has several similarities to human disease including tight skin, increased …