Informing endpoints for clinical trials of geographic atrophy
Geographic atrophy (GA), the non-neovascular advanced form of age-related macular
degeneration, remains an important disease area in which treatment needs are currently …
degeneration, remains an important disease area in which treatment needs are currently …
Association of complement C3 inhibitor pegcetacoplan with reduced photoreceptor degeneration beyond areas of geographic atrophy
Preservation of photoreceptors beyond areas of retinal pigment epithelium atrophy is a
critical treatment goal in eyes with geographic atrophy (GA) to prevent vision loss. Thus, we …
critical treatment goal in eyes with geographic atrophy (GA) to prevent vision loss. Thus, we …
Perspectives from clinical trials: is geographic atrophy one disease?
Geographic atrophy (GA) is currently an untreatable condition. Emerging evidence from
recent clinical trials show that anti-complement therapy may be a successful treatment …
recent clinical trials show that anti-complement therapy may be a successful treatment …
[HTML][HTML] Relationship of topographic distribution of macular atrophy secondary to neovascular AMD and reading performance
Purpose: The purpose of this study was to provide a topographical assessment of macular
atrophy in successfully treated neovascular age-related macular degeneration (AMD) eyes …
atrophy in successfully treated neovascular age-related macular degeneration (AMD) eyes …
The issue of end point discordance in dry age-related macular degeneration: how might clinical trials demonstrate a functional benefit?
Age-related macular degeneration (AMD) is a disorder of the macula characterized in its
early and intermediate stages by the presence of drusen and pigmentary abnormalities in …
early and intermediate stages by the presence of drusen and pigmentary abnormalities in …
[HTML][HTML] Progression of geographic atrophy: retrospective analysis of patients from the IRIS® Registry (Intelligent Research in Sight)
Purpose To evaluate disease progression and associated vision changes in patients with
geographic atrophy (GA) secondary to age-related macular degeneration (AMD) in 1 eye …
geographic atrophy (GA) secondary to age-related macular degeneration (AMD) in 1 eye …
Retinal OCT biomarkers associated with reading performance in patients with persistent vs. resolved diabetic macular edema
F Ricardi, I Reccalenda, G Boscia… - European Journal …, 2025 - journals.sagepub.com
Background Recent advancements in imaging technologies, particularly structural optical
coherence tomography (OCT), have improved the understanding of diabetic macular edema …
coherence tomography (OCT), have improved the understanding of diabetic macular edema …
Toward an internationally accepted standard for reading charts
W Radner - Progress in Retinal and Eye Research, 2024 - Elsevier
Patients who suffer from sight-threatening eye diseases share a desire to regain a
comfortable reading ability. In light of the modern advances achieved in ophthalmic …
comfortable reading ability. In light of the modern advances achieved in ophthalmic …
Efficacy οf Wet Age-related Macular Degeneration Treatment οn Reading: A Pilot Study Using Eye-movement Analysis
PURPOSE This study aimed to evaluate silent reading performance by means of eye fixation
analysis before and after anti-VEGF treatment in wAMD patients. METHODS Sixteen wAMD …
analysis before and after anti-VEGF treatment in wAMD patients. METHODS Sixteen wAMD …
Prosthetic Visual Acuity with the PRIMA System in Patients with Atrophic Age-related Macular Degeneration at 4 years follow-up
Objective: To assess the efficacy and safety of the PRIMA subretinal neurostimulation
system 48-months post-implantation for improving visual acuity (VA) in patients with …
system 48-months post-implantation for improving visual acuity (VA) in patients with …