Lysosomes and lysosomal hydrolases, including the cathepsins, have been shown to
change their properties with aging brain a long time ago, although their function was not …

It is more than 50years since the lysosome was discovered. Since then its hydrolytic
machinery, including proteases and other hydrolases, has been fairly well identified and …

The overall structure and architecture of the extracellular matrix undergo dramatic alterations
in composition, form, and functionality over time. The stochasticity begins during …

The endomembrane system consists of organellar membranes in the biosynthetic pathway
[endoplasmic reticulum (ER), Golgi apparatus, and secretory vesicles] as well as those in the …

OBJECTIVES: Contemporary adhesives lose their bond strength to dentin regardless of the
bonding system used. This loss relates to the hydrolysis of collagen matrix of the hybrid …

Background Cysteine cathepsins are normally found in the lysosomes where they are
involved in intracellular protein turnover. Their ability to degrade the components of the …

Investigations of Alzheimer's disease (AD), traumatic brain injury (TBI), and related brain
disorders have provided extensive evidence for involvement of cathepsin B, a lysosomal …

Cysteine cathepsins are highly upregulated in a wide variety of cancers by mechanisms
ranging from gene amplification to post-transcriptional modification. Their localization within …

Cysteine protease cathepsins have traditionally been considered as lysosome-restricted
proteases that mediate proteolysis of unwanted proteins. However, studies from the past …

Lysosomes figure prominently in theories of aging as the proteolytic system most
responsible for eliminating growing burdens of damaged proteins and organelles in aging …